Acute myeloid leukemia with myelodysplasia-related changes

Name
Acute myeloid leukemia with myelodysplasia-related changes
ICD-O-3 Morphology
9895/3
Effective 2001 and later
Reportable
for cases diagnosed 2001 and later
Primary Site(s)
C421

Help me code for dx year :

Grade
Code grade specified by pathologist. If no grade specified, code 9
Module Rule
M3 Module 5: PH10
Alternate Names
Acute myeloid leukemia with multilineage dysplasia
Acute myeloid leukemia with prior myelodysplastic syndrome
Acute myeloid leukemia without prior myelodysplastic syndrome
Definition
An acute leukemia with 20% or more blasts in blood or marrow, and dysplasia in 2 or more myeloid cell lines, generally including megakaryocytes. Dysplasia must be present in at least 50% of the cells of at least 2 lines. May occur de novo OR following myelodysplastic/myeloproliferative disorder.
Abstractor Notes
This is an AML with myelodysplasia-related changes. It is an acute leukemia with 20% or more PB or BM blasts with morphologic features of myelodysplasia OR a prior history of MDS OR myelodysplastic/myeloproliferative neoplasm OR MDS-related cytopenic abnormalities and without the specific genetic abnormalities of ANL with recurrent genetic abnormalities. These patients DO NOT have a history of prior cytotoxic or radiation therapy for an unrelated disease. The provisional diagnoses during work-up may include refractory anemia with excess blasts; acute erythroid leukemia, acute megakaryoblastic leukemia and AML, NOS.
Definitive Diagnostic Methods
Bone marrow biopsy
Peripheral blood
Genetics Data
-5/del(5q)
-7/del(7q)
-18
8
9
11
19
21
del(11q)
del(12p)
del(20q)
inv (3;3)
inv(3)(q21q26)
t 3q21
t 3q26
t(1;7)
t(2;11)
t(3;21)(q21;26)
t(3;5)(q25;q34)
Immunophenotyping
CD7
CD13
CD33
CD34+
CD38
CD56
Treatments
Chemotherapy
Transformations to
None
Corresponding ICD-9 Codes
205.0 Acute myeloid leukemia
Corresponding ICD-10 Codes
C92.0 Acute myeloid leukemia
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C92.A Acute myeloid leukemia with multilineage dysplasia
Signs and Symptoms
None
Diagnostic Exams
None
Recurrence and Metastases
None
Epidemiology and Mortality
None