SEER is an authoritative source of information on cancer incidence and survival in the United States. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population.
Most ALL patients present with widespread lymph node involvement as well as peripheral blood involvement. The number of circulating neoplastic cells does not correlate with the degree of bone marrow involvement, suggesting that circulating cells are recruited from other organs such as the skin. In fact, the skin is the most common extra-lymphatic site of involvement.
The disease is usually systemic, involving the spleen and extranodalsites including skin, lung, liver, GI tract and CNS.
Several clinical variants have been identified:
4. Smoldering ATLL
Patients often present with a high leukocyte count and often a large mediastinal mass or other tissuemass.
T-ALL comprises approximately 25% of adult ALL.