SEER is an authoritative source of information on cancer incidence and survival in the United States. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population.
This is a cytotoxic T-cell lymphoma, which preferentially infiltrates subcutaneous tissue, primarily involving the extremities. It is composed of atypical lymphoid cells of varying size, often with marked tumor necrosis and karyorrhexis. Per "The Lymphomas," typically, biopsies show lymphoid cells mixed with reactive histiocytes.
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) presents with multiple subcutaneous nodules, usually in the absence of other sites of disease. The most common sites of localization are the extremities and the trunk. The nodules range in size from 0.5 cm to several centimeters in diameter. Larger nodules may become necrotic, however ulceration is rare. The infiltrate involves the fat lobules, usually sparing the septa. The overlying dermis and epidermis are typically uninvolved. Dissemination to lymph nodes and other organs is rare.
The 5-year survival overall is 80%, but if a hemophagocytic syndrome is present the prognosis is poor.
SPTCL is a rare form of lymphoma, slightly more common in females than males and has a broad age range. Up to 20% may have associated autoimmune disease, most commonly systemic lupus erythematosus.