SEER is an authoritative source of information on cancer incidence and survival in the United States. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population.
Very rare disease characterized by lymphoid infiltrate in splenic white pulp growing in nodular pattern replacing pre-existing follicles with variable degree of red pulp infiltration; small lymphocytes predominant in central areas, medium-sized cells present in periphery. 66% present with circulating villous lymphocytes.
Splenomegaly is seen in almost all patients, commonly without lymphadenopathy. The bone marrow is frequently positive. Nodal and extranodal involvement are rare.
The lack of CD5 expression is helpful in the discrimination between SMZL and chronic lymphocyticleukemia/small lymphocyticlymphoma, and the lack of CD10 expression argues against follicular lymphoma. Mantle cell lymphoma is excluded due to the lack of CD5 and cyclin-D1 expression.