SEER is an authoritative source of information on cancer incidence and survival in the United States. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population.
Acute myeloid leukemia in which abnormal promyelocytes predominate
Acute promyelocytic leukemia is a malignancy of the bone marrow in which there is a deficiency of mature blood cells in the myeloid line of cells and an excess of immature cells called promyelocytes. APL is due to a translocation (an exchange of chromosome material) between chromosomes 15 and 17 which is symbolized t(15;17). This translocation is not a mere marker of APL. It is the cause of APL. APL is consistently associated with a disorder that resembles (but is not identical to) disseminated intravascular coagulation (DIC). In APL, there is a pronounced tendency to hemorrhage. The bleeding can manifest itself as petechiae (little bleeding spots in the skin or elsewhere), small ecchymoses (bruises), epistaxis (nose bleeds), bleeding in the mouth, hematuria (blood in the urine), bleeding from venipuncture and bone marrow sites, and girls and women who are menstruating may have menometrorrhagia (excessive irregular menstrual bleeding). The hemorrhagic diathesis may precede the diagnosis of leukemia by 2-8 weeks.
Definitive Diagnostic Methods
Bone Marrow biopsy
CD34 absent or low
Retinoic acid receptor alpha (RAR) on 17q12 fuses with 15q22 (PML gene)