Acute myelomonocytic leukemia

Name
Acute myelomonocytic leukemia
ICD-O-1 Morphology
9867/3
Effective 1978 - 1991
ICD-O-2 Morphology
9867/3
Effective 1992 - 2000
ICD-O-3 Morphology
9867/3
Effective 2001 and later
Reportable
for cases diagnosed 1978 and later
Primary Site(s)
C421

Help me code for diagnosis year :

Grade
Code grade specified by pathologist. If no grade specified, code 9
Module Rule
M3 Module 5: PH10
Alternate Names
Acute myeloid leukemia, M4
AMML
AMMoL
FAB M4
Definition
AMML is an acute leukemia characterized by the proliferation of both neutrophil and monocyte precursors. The bone marrow has 20% or more blasts; neutrophils and their precursors, plus monocytes and their precursors each comprise 20% or more of marrow cells. A high number of circulating blood monocytic cells may be present.
Form of acute myeloid leukemia which involves a proliferation of CFU-GM myeloblasts and monoblasts.
Abstractor Notes
The peripheral blood (PB) and bone marrow (BM) have more than 20% blasts, neutrophils and their precursors, plus monocytes and their precursors. The monocyte component may be more evident in the PB than in the BM. The preliminary diagnosis may include AML with maturation, AML without maturation and AML. The diagnosis of AML is proven by BM biopsy. Patients typically present with anemia, thrombocytopenia, fever and fatigue. The WBC may be high.
Definitive Diagnostic Methods
Bone marrow
Immunophenotyping
Peripheral blood
Genetics Data
None
Immunophenotyping
CD4+
CD7+ (approximately 30% of cases)
CD11b+
CD11c+
CD13+
CD14+
CD15+
CD33+
CD34+
CD36+
CD64+
CD65+
CD117+
CD163+
HLA-DR
Macrophage-restricted CD68 (PGM1)
Treatments
Bone marrow transplant
Chemotherapy
Transformations to
No Transformations
Corresponding ICD-9 Codes
205.0 Acute myeloid leukemia
Corresponding ICD-10 Codes
C92.5 Acute myelomonocytic leukemia
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C92.5 Acute myelomonocytic leukemia
Signs and Symptoms
None
Diagnostic Exams
None
Recurrence and Metastases
None
Epidemiology and Mortality
None