SEER is an authoritative source of information on cancer incidence and survival in the United States. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population.
Code grade specified by pathologist. If no grade specified, code 9
M3 Module 5: PH10
Acute myeloid leukemia, M4
AMML is an acute leukemia characterized by the proliferation of both neutrophil and monocyte precursors. The bone marrow has 20% or more blasts; neutrophils and their precursors, plus monocytes and their precursors each comprise 20% or more of marrow cells. A high number of circulating blood monocytic cells may be present. Form of acute myeloid leukemia which involves a proliferation of CFU-GM myeloblasts and monoblasts.
The peripheral blood (PB) and bone marrow (BM) have more than 20% blasts, neutrophils and their precursors, plus monocytes and their precursors. The monocyte component may be more evident in the PB than in the BM. The preliminary diagnosis may include AML with maturation, AML without maturation and AML. The diagnosis of AML is proven by BM biopsy. Patients typically present with anemia, thrombocytopenia, fever and fatigue. The WBC may be high.