T-cell/histiocyte-rich large B-cell lymphoma

Name
T-cell/histiocyte-rich large B-cell lymphoma
ICD-O-3 Morphology
9688/3
Effective 2010 and later
Reportable
for cases diagnosed 2010 and later
Primary Site(s)
C770-C779

Help me code for dx year :

Grade
6 - B-cell
Module Rule
None
Alternate Names
Histiocyte rich/T-cell rich large B-cell lymphoma
Large B-cell lymphoma rich in T-cells and simulating Hodgkin disease
T-cell rich B-cell lymphoma
THRLBCL
Definition
This neoplasm is characterized by a limited number of scattered, large, atypical B cells embedded in a background of abundant T cells and frequently histiocytes which are useful for diagnosis.
Abstractor Notes
(This code is effective for cases diagnosed 2010 and later.) THRLBCL mainly affects the lymph nodes but bone marrow, liver and spleen involvement are frequently found at diagnosis. Most patients present at advanced stages (Stage IV with bone marrow involvement). Patients present with fever, malaise, splenomegaly and/or hepatomegaly. This disease is often refractory to chemotherapy. Most frequently treated with CHOP.

If cells are EBV positive, need to reconsider diagnosis (DLBCL). This is an aggressive lymphoma.

Preferred primary sites are listed for this disease in the primary site field; however, involvement in other sites is possible, but rare. If you have confirmation that the only involved site is something other than the preferred primary listed, then code to that primary site.
Definitive Diagnostic Methods
Histologic confirmation
Immunophenotype
Genetics Data
Clonal rearrangement of IG genes in tumor B-cells
Immunophenotyping
BCL2
BCL6
CD3+ T-cells
CD5+ T-cells
CD68+ histiocytes
EMA
Treatments
Chemotherapy
Hormone
Radiation
Transformations from
None
Corresponding ICD-9 Codes
200.7 Large cell lymphoma
Corresponding ICD-10 Codes
C83.3 Diffuse non-Hodgkins lymphoma, large cell (diffuse)
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C83.3 Diffuse large B-cell lymphoma
Signs and Symptoms
None
Diagnostic Exams
None
Recurrence and Metastases
None
Epidemiology and Mortality
None