Acute myeloid leukemia with minimal differentiation

Name
Acute myeloid leukemia with minimal differentiation
ICD-O-3 Morphology
9872/3
Effective 2001 and later
Reportable
for cases diagnosed 2001 and later
Primary Site(s)
C421
Primary site must be bone marrow (C421)

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Grade
Code grade specified by pathologist. If no grade specified, code 9
Module Rule
See abstractor notes
Alternate Names
Acute myeloblastic leukemia, minimally differentiated
Acute myeloid leukemia, M0
FAB M0
Definition
An acute leukemia with no evidence of myeloid differentiation by morphology and/or light microscopy cytochemistry. The myeloid nature of the blasts is demonstrated by immunological markers and/or ultrastructural cytochemistry.
Abstractor Notes
This AML has little or no evidence of myeloid differentiation by morphology and light microscopy cytochemistry. The disease is identified by immunophenotyping and/or ultrastructural cytochemistry. Immunophenotyping is essential to distinguish this neoplasm from ALL.

If the leukemia occurs before or simultaneously with Myeloid Sarcoma (9930/3), see M3 and Module 5:PH10.
Definitive Diagnostic Methods
Genetic testing
Immunophenotyping
Genetics Data
FLT3
RUNX1(AML1)
Immunophenotyping
CD13
CD33
CD34+ (in approx. 70% of cases)
CD38
CD117
HLA-DR+ (in approx. 70% of cases)
Treatments
Chemotherapy
Stem cell transplant
Transformations to
None
Corresponding ICD-9 Codes
205.0 Acute myeloid leukemia
Corresponding ICD-10 Codes
C92.0 Acute myeloid leukemia
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C92.0 Acute myeloblastic leukemia
Signs and Symptoms
Anemia
Bone marrow failure
Easy bruising or bleeding
Fatigue
Fever
Petechiae
Shortness of breath
Weakness
Weight loss or loss of appetite
Diagnostic Exams
Recurrence and Metastases
None
Epidemiology and Mortality
Age: most common in either infants or older adults
Incidence: <5% of all AML cases