SEER is an authoritative source of information on cancer incidence and survival in the United States. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population.
9 - Grade/differentiation unknown, not stated, or not applicable
Atypical chronic myeloid leukemia
Philadelphia chromosome (PH1) negative
aCML is a leukemic disorder with myelodysplastic as well as myeloproliferative features. It is characterized by principal involvement of the neutrophil series with leukocytosis comprised of immature and mature neutrophils that are dysplastic. Mutilineage dysplasia; however, is common and reflects the stem cell origin.
Atypical CML BCR-ABL1 negative is a rare disease. Although most patients are in their 70s or 80s, there have been cases reported in teenagers. The peripheral blood and bone marrow are always involved; spleen and hepatic involvement are common. The chief complaint of patients is splenomegaly. Most patients have symptoms related to anemia or occasionally thrombocytopenia. The physician will run tests to rule out BCR-ABL1 involvement. Patients with aCML fare poorly. The series reported to the present time include only small numbers of patients but median survival times range from 14-29 months.