SEER Stat Fact Sheets: Non-Hodgkin Lymphoma
Lifetime risk estimates are not available with the current statistics release, but will be added later when population data for older age groups are available.
Statistics at a GlanceShow More
At a Glance
- Estimated New Cases in 2016 72,580
- Estimated Deaths in 2016 20,150
Number of New Cases and Deaths per 100,000: The number of new cases of non-Hodgkin lymphoma was 19.5 per 100,000 men and women per year. The number of deaths was 6.0 per 100,000 men and women per year. These rates are age-adjusted and based on 2009-2013 cases and deaths.
Lifetime Risk of Developing Cancer: Approximately 2.1 percent of men and women will be diagnosed with non-Hodgkin lymphoma at some point during their lifetime, based on 2010-2012 data.
Prevalence of This Cancer: In 2013, there were an estimated 569,536 people living with non-Hodgkin lymphoma in the United States.
Survival StatisticsShow More
How Many People Survive 5 Years Or More after Being Diagnosed with Non-Hodgkin Lymphoma?
Relative survival statistics compare the survival of patients diagnosed with cancer with the survival of people in the general population who are the same age, race, and sex and who have not been diagnosed with cancer. Because survival statistics are based on large groups of people, they cannot be used to predict exactly what will happen to an individual patient. No two patients are entirely alike, and treatment and responses to treatment can vary greatly.
Based on data from SEER 18 2006-2012. Gray figures represent those who have died from non-Hodgkin lymphoma. Green figures represent those who have survived 5 years or more.
Survival by Stage
Cancer stage at diagnosis, which refers to extent of a cancer in the body, determines treatment options and has a strong influence on the length of survival. In general, if the cancer is found only in the part of the body where it started it is localized (sometimes referred to as stage 1). If it has spread to a different part of the body, the stage is regional or distant. For non-Hodgkin lymphoma, 27.5% are diagnosed at the local stage. The 5-year survival for localized non-Hodgkin lymphoma is 82.6%.
- Localized (28%)
Confined to Primary Site
- Regional (15%)
Spread to Regional Lymph Nodes
- Distant (50%)
Cancer Has Metastasized
- Unknown (8%)
SEER 18 2006-2012, All Races, Both Sexes by SEER Summary Stage 2000
Number of New Cases and DeathsShow More
How Common Is This Cancer?
Compared to other cancers, non-Hodgkin lymphoma is fairly common.
|Common Types of Cancer||Estimated New
|1.||Breast Cancer (Female)||246,660||40,450|
|2.||Lung and Bronchus Cancer||224,390||158,080|
|4.||Colon and Rectum Cancer||134,490||49,190|
|6.||Melanoma of the Skin||76,380||10,130|
|9.||Kidney and Renal Pelvis Cancer||62,700||14,240|
Non-Hodgkin lymphoma represents 4.3% of all new cancer cases in the U.S.
In 2016, it is estimated that there will be 72,580 new cases of non-Hodgkin lymphoma and an estimated 20,150 people will die of this disease.
Who Gets This Cancer?
Non-Hodgkin lymphoma is more common in men than women, and among individuals of Caucasian descent. The number of new cases of non-Hodgkin lymphoma was 19.5 per 100,000 men and women per year based on 2009-2013 cases.
Non-Hodgkin lymphoma is most frequently diagnosed among people aged 65-74.
SEER 18 2009-2013, All Races, Both Sexes
- All Races
- Asian /
- American Indian /
SEER 18 2009-2013, Age-Adjusted
Who Dies From This Cancer?
Non-Hodgkin lymphoma is the eighth leading cause of cancer death in the United States. The number of deaths was 6.0 per 100,000 men and women per year based on 2009-2013 deaths.
The percent of non-Hodgkin lymphoma deaths is highest among people aged 75-84.
U.S. 2009-2013, All Races, Both Sexes
- All Races
- Asian /
- American Indian /
U.S. 2009-2013, Age-Adjusted
Trends in RatesShow More
Changes Over Time
Keeping track of the number of new cases, deaths, and survival over time (trends) can help scientists understand whether progress is being made and where additional research is needed to address challenges, such as improving screening or finding better treatments.
Using statistical models for analysis, rates for new non-Hodgkin lymphoma cases have not changed significantly over the last 10 years. Death rates have been falling on average 2.4% each year over 2004-2013. 5-year survival trends are shown below the figure.
|5-Year Relative Survival||45.8%||49.1%||52.4%||49.7%||51.9%||63.8%||70.1%||72.5%|
SEER 9 Incidence & U.S. Mortality 1975-2013, All Races, Both Sexes. Rates are Age-Adjusted.
More About This CancerShow More
The lymphatic system is part of the immune system. The lymphatic system includes lymph vessels that branch into all the tissues of the body; lymph, clear fluid that contains white blood cells, especially lymphocytes such as B cells and T cells; and lymph nodes, where lymph vessels are connected to small, round masses of tissue. Groups of lymph nodes are found in the neck, underarms, chest, abdomen, and groin. Lymph nodes store white blood cells. They trap and remove bacteria or other harmful substances that may be in the lymph.
There are many different types of non-Hodgkin lymphoma. These types can be divided into aggressive (fast-growing) and indolent (slow-growing) types, and they can be formed from either B-cells or T-cells. B-cell non-Hodgkin lymphomas include Burkitt lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma, follicular lymphoma, immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma, and mantle cell lymphoma. T-cell non-Hodgkin lymphomas include mycosis fungoides, anaplastic large cell lymphoma, and precursor T-lymphoblastic lymphoma.
Other parts of the lymphatic system include the tonsils, thymus, and spleen. Lymphatic tissue is also found in other parts of the body including the stomach, skin, and small intestine. Because lymphatic tissue is in many parts of the body, lymphoma can start almost anywhere. Usually, it's first found in a lymph node.
Here are some resources for learning more about non-Hodgkin lymphoma.
- More about risk factors for non-Hodgkin lymphoma
- More about symptoms and diagnosis of non-Hodgkin lymphoma
- More about treatment options for non-Hodgkin lymphoma
- More about clinical trials
- More about cancer prevention
All statistics in this report are based on statistics from SEER and the Centers for Disease Control and Prevention's National Center for Health Statistics. Most can be found within:
Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2013, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2013/, based on November 2015 SEER data submission, posted to the SEER web site, April 2016.
All material in this report is in the public domain and may be reproduced or copied without permission; citation as to source, however, is appreciated.
SEER Cancer Statistics Factsheets: Non-Hodgkin Lymphoma. National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/statfacts/html/nhl.html
This factsheet focuses on population statistics that are based on the US population. Because these statistics are based on large groups of people, they cannot be used to predict exactly what will happen to an individual patient. To see tailored statistics, browse the SEER Cancer Statistics Review. To see statistics for a specific state, go to the State Cancer Profiles.
The statistics presented in this factsheet are based on the most recent data available, most of which can be found in the SEER Cancer Statistics Review. In some cases, different year spans may be used. Estimates for the current year are based on past data.
Cancer is a complex topic. There is a wide range of information available. This factsheet does not address causes, symptoms, diagnosis, treatment, follow-up care, or decision making, although it provides links to information in many of these areas.