Multiple Primary - Standardized Incidence/Mortality Ratios (MP-SIR/SMR)
MP-SIR is a method used to perform multiple primary analyses and to test hypotheses that explore theoretical links in the etiology of two cancers. A defined cohort of persons previously diagnosed with cancer is followed through time to compare their subsequent cancer experience to the number of cancers that would be expected based on incidence rates for the general population.
MP-SMR follows a cohort of persons through time to compare their observed mortality experience to the expected mortality based on U.S. mortality rates.
Multiple Primary - Standardized Incidence/Mortality Ratios can be calculated in SEER*Stat.
MP-SIR/SMR statistic types available in SEER*Stat
SIR/SMR Tables Observed, Expected, O/E, and Excess Risk statistics
Frequency counts across multiple primaries
Case Listings with advanced sorting capability
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Rothman KJ, Boice JD. Epidemiologic analysis with a programmable calculator. 2nd ed. Newton, MA: Epidemiology Resources, 1982.