Acute myeloid leukemia (megakaryoblastic) with t(1;22)(p13;q13); RBM15-MKL1

Name
Acute myeloid leukemia (megakaryoblastic) with t(1;22)(p13;q13); RBM15-MKL1
ICD-O-3 Morphology
9911/3
Effective 2010 and later
Reportable
for cases diagnosed 2010 and later
Primary Site(s)
C421

Help me code for diagnosis year :

Grade
Code grade specified by pathologist. If no grade specified, code 9
Module Rule
M3 Module 5: PH10
Alternate Names
None
Definition
This is an AML generally showing maturation in the megakaryocyte lineage. This occurs most commonly in infants with Downs Syndrome with a female predominance. This disease is restricted to infants and young children with most cases occuring in the first 6 months of life.
Abstractor Notes
(This code is effective for cases diagnosed 2010 and later. For cases diagnosed prior to 2010 see code 9910/3. ) Most commonly occurs in infants without Downs syndrome. The vast majority of cases present with marked organomegaly, especially hepatosplenomegaly. Patients also have anemia, thrombocytopenia and a moderately elevated white blood count.
Definitive Diagnostic Methods
Cytogenetics on bone marrow
Cytogenetics on peripheral blood
Genetics Data
RBM15 (aka OTT)
RBM15-MKL1 fusion
t(1;22)(p13;q13)
Immunophenotyping
CD13+
CD33+
CD34-
CD36+
CD41(glycoprotein IIb/IIIa)
CD42 (glycoprotein Ib-less frequent)
CD45-
CD61 (glycoprotein IIIa)
HLA-DR-
Treatments
Chemotherapy
Transformations to
None
Corresponding ICD-9 Codes
205.0 Acute myeloid leukemia
Corresponding ICD-10 Codes
C92.0 Acute myeloid leukemia
Corresponding ICD-10-CM Codes (effective October 1, 2015 U.S. only)
C92.0 Acute myeloblastic leukemia
Signs and Symptoms
None
Diagnostic Exams
None
Recurrence and Metastases
None
Epidemiology and Mortality
None