This neoplasm is not reportable.

Name

Non-IgM monoclonal gammopathy of undetermined significance

ICD-O-2 Morphology

9765/1: Monoclonal gammopathy
Effective 1992 - 2000

ICD-O-3 Morphology

9765/1: Monoclonal gammopathy
Effective 2001 and later

Not Reportable

This neoplasm is not reportable

Primary Site(s)

See Abstractor Notes

Alternate Names

Benign monoclonal gammopathy
Idiopathic paraproteinemia
MGUS
Monoclonal gammopathy, NOS
Monoclonal gammopathy of undetermined significance, IgG/A
Monoclonal gammopathy of undetermined significance, IgM (see 9761/1)
Monoclonal gammopathy of undetermined significance, NOS
Monoclonal gammopathy, unassociated
Monoclonal gammopathy, unattributed
Non-myelomatous gammopathy

Definition

Non-IgM (plasma cell) MGUS is defined as the presence in the serum of an IgG, IgA, or (rarely) IgD M protein at a concentration of < 30 grams per liter; clonal bone marrow plasma cells < 10%; and absence of end organ damage such as hypercalcemia, renal insufficiency, anemia, and bone lesions (CRAB) and amyloidosis, attributable to the plasma cell proliferative disorder.

MGUS progresses to malignant multiple myeloma at a rate of 1% per year.

Definitive Diagnostic Methods

This data item does not apply

Genetics Data

This data item does not apply

Immunophenotyping

This data item does not apply

Corresponding ICD-9 Codes

273.1 Monoclonal paraproteinemia

Corresponding ICD-10 Codes

D47.2 Monoclonal gammopathy

Corresponding ICD-10-CM Codes (U.S. only)

D47.2 Monoclonal gammopathy (effective October 01, 2015)

Sources

Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Mature B-cell neoplasms
Pages: 241-243

International Classification of Diseases for Oncology, Third Edition, First Revision. Geneva: World Health Organization, 2013.
Section: ICD-O-3.1 (2011) Morphological Codes
Pages: http://codes.iarc.fr/codegroup/2

National Cancer Institute
Section: General Information About Plasma Cell Neoplasms
Pages: https://www.cancer.gov/types/myeloma/hp/myeloma-treatment-pdq
Glossary