The SEER Data Management System (SEER*DMS) provides support for all core cancer registry functions -- importing data, editing, linkage, consolidation, and reporting. The individual SEER Registries actively participated in the requirements analysis and design of SEER*DMS. It was determined that despite the variety, number, and complexity of the registries’ processes and corresponding functional requirements, a centrally designed data management system could be employed by the various SEER Registries. SEER*DMS improves cost efficiency and reduces duplication of effort in terms of system maintenance and administration. Furthermore, the centralized system design and development improves data quality and consistency, increases efficiency, and increases the sharing of knowledge and experience among registries. Future development of SEER*DMS is handled by the Change Control Board.