ICD-O-3 Morphology

Effective 2010 and later

Reportable

for cases diagnosed 2010 and later

Primary Site(s)

C421
Primary site must be bone marrow (C421)

Grade

Not Applicable

Module Rule

None

Alternate Names

None

Definition

Refractory neutropenia is characterized by >=10% dysplastic neutrophils in the peripheral blood or bone marrow; the dysplasia is principally manifest as nuclear hypolobation and hypogranulation.

Abstractor Notes

(This code is effective for cases diagnosed 2010 and later. For cases diagnosed prior to 2010, see code 9989/3.)

Neutropenia secondary to drug therapy, toxic exposure, infectious processes, immune mechanisms, or other causative factors must be excluded. The other myeloid cell lines do not show significant dysplasia.

For MDS diseases (9980, 9982, 9983, 9985, 9986, 9989, 9991, 9992), abstracting each of the subtypes would result in over-counting of the diseases.
1, Code only the first subtype that is diagnosed.
2. Do not change the histology code or create a new abstract for any subsequent specific MDS subtypes.

For more information on myelodysplastic syndromes, see the NCI website: http://www.cancer.gov/types/myeloproliferative/hp/myelodysplastic-treatment-pdq#section/_1 or http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq#section/_1

Definitive Diagnostic Methods

Bone marrow biopsy
Peripheral blood smear

Genetics Data

None

Immunophenotyping

None

Treatments

None

Transformations to

There are no known transformations

Transformations from

There are no known transformations

Corresponding ICD-9 Codes

238.72 Low grade myelodysplastic syndrome lesions

Corresponding ICD-10 Codes

D46.0 Refractory anemia without sideroblasts, so stated

Corresponding ICD-10-CM Codes (U.S. only)

D46.0 Refractory anemia without ring sideroblasts, so stated (effective October 01, 2015)

Signs and Symptoms

Easy bruising or bleeding
Pale skin
Shortness of breath
Weakness

Progression and Transformation

None

Epidemiology and Mortality

None

Sources

None
Glossary