ICD-O-3 Morphology

Effective 2010 and later

Reportable

for cases diagnosed 2010 and later

Primary Site(s)

C421
Primary site must be bone marrow (C421)

Grade

Not Applicable

Module Rule

None

Alternate Names

RT

Definition

Refractory thrombocytopenia is characterized by >10% dysplastic megakaryocytes of at least 30 megakaryocytes.

Abstractor Notes

(This code is effective for cases diagnosed 2010 and later. For cases diagnosed prior to 2010, see code 9989/3.)

Thrombocytopenia is an abnormal drop in the number of platelets which are involved in forming blood clots. Distinction between Refractory thrombocytopenia and other chronic autoimmune thrombocytopenia is critical and may be extremely difficult clinically and morphologically. Cytogenetic studies may be of considerable aid in this distinction. Cytogenetic abnormalities may be found in up to 50% of cases.

For MDS diseases (9980, 9982, 9983, 9985, 9986, 9989, 9991, 9992), abstracting each of the subtypes would result in over-counting of the diseases.
1. Code only the first subtype that is diagnosed.
2. Do not change the histology code or create a new abstract for any subsequent specific MDS subtypes.

For more information on myelodysplastic syndromes, see the NCI website: http://www.cancer.gov/types/myeloproliferative/hp/myelodysplastic-treatment-pdq#section/_1 or http://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq#section/_1

Definitive Diagnostic Methods

Clinical diagnosis
Genetic testing

Genetics Data

Abnormalities of 5 and/or 6
del(20q), =8

Immunophenotyping

None

Treatments

None

Transformations from

None

Corresponding ICD-9 Codes

238.72 Low grade myelodysplastic syndrome lesions

Corresponding ICD-10 Codes

D46.0 Refractory anemia without sideroblasts, so stated

Corresponding ICD-10-CM Codes (U.S. only)

D46.0 Refractory anemia without ring sideroblasts, so stated (effective October 01, 2015)

Signs and Symptoms

Easy bruising or bleeding
Pale skin
Shortness of breath
Weakness

Progression and Transformation

None

Epidemiology and Mortality

None

Sources

None
Glossary