Reactive B-cell-rich lymphoid proliferations that can mimic lymphoma

Reactive B-cell-rich lymphoid proliferations that can mimic lymphoma is part of the Tumor like lesion with B-cell predominance lineage table in the WHO 5th edition of Hematolymphoid Tumors. (See Appendix B in the Hematopoietic Manual, Table B13)

Patients present with lymphadenopathy, enlarged tonsils or salivary glands, and/or mucosal ulceration. Symptoms vary by cause and organs involved. Manifestations may be more severe in immunodeficient patients.

Reactive conditions mimicking lymphoma include (but not limited to):
1. Florid follicular hyperplasia
2. Systemic lupus erythematosus
3. Sjogren syndrome
4. Lymphoma-like-lesion of the female genital tract
5. Rectal tonsil
6. Marginal zone hyperplasia
7. Postvaccination lymphadenitis
8. Infectious mononucleosis
9. Cytomegalovirus syndrome (CMV)
10. Indolent B-lymphoblastic proliferation (hematogone hyperplasia)

Acquired lymphocytosis

Lymphadenitis

These are non-neoplastic proliferations of lymphoid tissue in nodal or extranodal sites that may occasionally or frequently resemble B-cell lymphoma. (WHO 5th ed).

WHO Classification of Tumours Editorial Board. Haematolymphoid tumours. Lyon (France): International Agency for Research on Cancer; 2024. (WHO classification of tumours series, 5th ed.; vol. 11). https://publications.iarc.who.int/637.
Section: B-cell lymphoid proliferations and lymphomas
Pages: Par B: 309-314