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This neoplasm is not reportable.
Name
Paraneoplastic syndromes
Reportability
This neoplasm is not reportable
Abstractor Notes
Plasma cell neoplasms with associated paraneoplastic syndrome are part of the Plasma cell neoplasms and other diseases with paraproteins lineage table in the WHO 5th edition of Hematolymphoid Tumors. (See Appendix B in the Hematopoietic Manual, Table B17)
This is a group of rare paraneoplastic syndromes associated with plasma cell neoplasms. These syndromes are not reportable; however, these may occur in the setting of a reportable neoplasm. If that happens, code to the reportable neoplasm.
AESOP syndrome (adenopathy and extensive skin patch overlying plasmacytoma). Rare occurrence in the presentation of solitary plasmacytoma.
POEMS syndrome (see POEMS entry)
TEMPI syndrome (see TEMPI entry)
This is a group of rare paraneoplastic syndromes associated with plasma cell neoplasms. These syndromes are not reportable; however, these may occur in the setting of a reportable neoplasm. If that happens, code to the reportable neoplasm.
AESOP syndrome (adenopathy and extensive skin patch overlying plasmacytoma). Rare occurrence in the presentation of solitary plasmacytoma.
POEMS syndrome (see POEMS entry)
TEMPI syndrome (see TEMPI entry)
Definition
This is a group of rare paraneoplastic syndromes associated with plasma cell neoplasms: POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes), TEMPI syndrome (telangiectasias, elevated erythropoietin and erythrocytosis, monoclonal gammopathy, perinephric fluid collection, and intrapulmonary shunting), and AESOP syndrome (adenopathy and extensive skin patch overlying plasmacytoma). (WHO 5th edition)
Signs and Symptoms
Sources
WHO Classification of Tumours Editorial Board. Haematolymphoid tumours. Lyon (France): International Agency for Research on Cancer; 2024. (WHO classification of tumours series, 5th ed.; vol. 11). https://publications.iarc.who.int/637.
Section: Plasma cell neoplasms and other diseases with paraproteins
Pages: Part B: 631-633
Section: Plasma cell neoplasms and other diseases with paraproteins
Pages: Part B: 631-633
PDQ® Adult Treatment Editorial Board. PDQ Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment. Bethesda, MD: National Cancer Institute. Updated <03/28/2025>. Available at: https://www.cancer.gov/types/myeloma/hp/myeloma-treatment-pdq. Accessed <03/30/2025>. [PMID: 26389362]
Section: Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment (PDQ®)–Health Professional Version
Pages: https://www.cancer.gov/types/myeloma/hp/myeloma-treatment-pdq
Section: Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment (PDQ®)–Health Professional Version
Pages: https://www.cancer.gov/types/myeloma/hp/myeloma-treatment-pdq
