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This neoplasm is not reportable.
Name
Fanconi anemia
Reportability
This neoplasm is not reportable
Abstractor Notes
Fanconi anemia is part of the Genetic tumour syndromes associated with hematolymphoid tumours table in the WHO 5th edition of Hematolymphoid Tumors. (See Appendix B in the Hematopoietic Manual, Table B22)
FA is characterized by a range of physical abnormalities, progressive bone marrow failure, and an increased risk for cancer. The most common neoplasms associated with FA are myelodysplastic neoplasms, acute myeloid leukaemia, and squamous cell carcinoma of the head and neck.
Fanconi anemia is not reportable; however, any cancers related to Fanconi anemia are.
FA is characterized by a range of physical abnormalities, progressive bone marrow failure, and an increased risk for cancer. The most common neoplasms associated with FA are myelodysplastic neoplasms, acute myeloid leukaemia, and squamous cell carcinoma of the head and neck.
Fanconi anemia is not reportable; however, any cancers related to Fanconi anemia are.
Definition
Fanconi anemia (FA) is a clinically and genetically heterogeneous disorder caused by germline variants in the FA/BRCA DNA repair pathway, resulting in chromosomal breakage and hypersensitivity to crosslinking agents. Characteristic clinical features include developmental abnormalities in major organ systems, early-onset bone marrow failure, endocrine anomalies, and a high predisposition to cancer.
Sources
WHO Classification of Tumours Editorial Board. Haematolymphoid tumours. Lyon (France): International Agency for Research on Cancer; 2024. (WHO classification of tumours series, 5th ed.; vol. 11). https://publications.iarc.who.int/637.
