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This neoplasm is not reportable.
Name
Myeloid neoplasms associated with germline predisposition
Reportability
This neoplasm is not reportable
Abstractor Notes
Myeloid neoplasms associated with germline predisposition is part of the Secondary myeloid lineage table in the WHO 5th edition of Hematolymphoid Tumors. (See Appendix B in the Hematopoietic Manual, Table B7)
This heterogeneous group of diseases is caused by deleterious germline pathogenic or likely pathogenic (P/LP) variants in genes that affect critical biological pathways leading to varying abnormalities of benign, malignant, hematopoietic, or/and non-hematopoietic disorders.
This heterogeneous group of diseases is caused by deleterious germline pathogenic or likely pathogenic (P/LP) variants in genes that affect critical biological pathways leading to varying abnormalities of benign, malignant, hematopoietic, or/and non-hematopoietic disorders.
Definition
Myeloid neoplasms associated with germline predisposition include acute myeloid leukaemia (AML), myelodysplastic neoplasms (MDSs), myeloproliferative neoplasms, and myelodysplastic/myeloproliferative neoplasms that arise in individuals with genetic conditions associated with increased risk of myeloid malignancies.
Sources
WHO Classification of Tumours Editorial Board. Haematolymphoid tumours. Lyon (France): International Agency for Research on Cancer; 2024. (WHO classification of tumours series, 5th ed.; vol. 11). https://publications.iarc.who.int/637.
Section: Myeloid proliferations and neoplasms
Pages: Part A: 173-181
Section: Myeloid proliferations and neoplasms
Pages: Part A: 173-181
