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This neoplasm is not reportable.
Name
POEMS syndrome
Reportability
This neoplasm is not reportable
Abstractor Notes
POEMS syndrome is part of the Plasma cell neoplasms and other diseases with paraproteins lineage table in the WHO 5th edition of Hematolymphoid Tumors. (See Appendix B in the Hematopoietic Manual, Table B17).
The POEMS acronym stands for
1. Polyneuropathy
2. Organomegaly
3. Endocrinopathy
4. Monoclonal gammopathy
5. Skin changes
The POEMS acronym stands for
1. Polyneuropathy
2. Organomegaly
3. Endocrinopathy
4. Monoclonal gammopathy
5. Skin changes
Definition
POEMS syndrome is a paraneoplastic syndrome associated with a plasma cell neoplasm, usually characterized by fibrosis and osteosclerotic changes in bone trabeculae, and often with lymph node changes resembling the plasma cell variant of Castleman disease. (WHO 5th edition)
Sources
WHO Classification of Tumours Editorial Board. Haematolymphoid tumours. Lyon (France): International Agency for Research on Cancer; 2024. (WHO classification of tumours series, 5th ed.; vol. 11). https://publications.iarc.who.int/637.
