An official website of the United States government
Home
This neoplasm is not reportable.
Abstractor Notes
The most common site of involvement is the oral cavity, including gingiva. The outgrowth of the EBV-positive cells may be related to local trauma or inflammation.
Patients present with ulcerated lesions, usually in the oral mucosa (tonsils, tongue, buccal mucosa, and palate), skin, and gastrointestinal tract (esophagus, large bowel, rectum, and perianal region). Regional isolated lymphadenopathy is rarely seen, but there is no evidence of systemic lymphadenopathy, hepatosplenomegaly, or bone marrow involvement. Regional lymph nodes may show reactive hyperplasia.
Patients present with ulcerated lesions, usually in the oral mucosa (tonsils, tongue, buccal mucosa, and palate), skin, and gastrointestinal tract (esophagus, large bowel, rectum, and perianal region). Regional isolated lymphadenopathy is rarely seen, but there is no evidence of systemic lymphadenopathy, hepatosplenomegaly, or bone marrow involvement. Regional lymph nodes may show reactive hyperplasia.
Alternate Names
EBVMCU
EBV+ mucocutaneous ulcer
Definition
EBV-positive mucocutaneous ulcer (EBVMCU) is a newly recognized clinicopathological entity occurring in patients with age-related or iatrogenic immunosuppression, often with Hodgkin-like features and a typically indolent course, with spontaneous regression in some cases. It presents in cutaneous or mucosal sites.
Transformations to
This data item does not apply
Corresponding ICD-9 Codes
238.79 Other lymphatic and hematopoietic tissues
Corresponding ICD-10 Codes
D47.7 Other specified neoplasms of uncertain or unknown behavior of lymphoid, hematopoietic, and related tissue
Corresponding ICD-10-CM Codes (U.S. only)
D47.Z9 Other specified neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue (effective October 01, 2015)
Sources
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Mature B-cell neoplasms
Pages: 307-308
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Mature B-cell neoplasms
Pages: 307-308
International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577
