An official website of the United States government
Home
Name
Trametinib
Alternate Names
Mekinist
Abbreviations
None
Category
Chemotherapy
Subcategory
MEK inhibitor
NSC Number
763093
Primary Site
Melanoma
Thyroid
Histology
None
Remarks
Trametinib received FDA approval May 29, 2013 for the treatment of metastatic or unresectable melanoma.
June 30, 2017 FDA granted regular approvals to dabrafenib and trametinib (Tafinlar and Mekinist) administered in combination for patients with metastatic non-small cell lung cancer with BRAF V600E mutation as detected by an FDA-approved test. The two agents, sponsored by Novartis, are the first FDA approvals specifically for treatment of patients with BRAF V600E mutation-positive metastatic NSCLC.
5/4/2018 The U.S. Food and Drug Administration approved Tafinlar (dabrafenib) and Mekinist (trametinib), administered together, for the treatment of anaplastic thyroid cancer (ATC) that cannot be removed by surgery or has spread to other parts of the body (metastatic), and has a type of abnormal gene, BRAF V600E (BRAF V600E mutation-positive).
June 30, 2017 FDA granted regular approvals to dabrafenib and trametinib (Tafinlar and Mekinist) administered in combination for patients with metastatic non-small cell lung cancer with BRAF V600E mutation as detected by an FDA-approved test. The two agents, sponsored by Novartis, are the first FDA approvals specifically for treatment of patients with BRAF V600E mutation-positive metastatic NSCLC.
5/4/2018 The U.S. Food and Drug Administration approved Tafinlar (dabrafenib) and Mekinist (trametinib), administered together, for the treatment of anaplastic thyroid cancer (ATC) that cannot be removed by surgery or has spread to other parts of the body (metastatic), and has a type of abnormal gene, BRAF V600E (BRAF V600E mutation-positive).
Coding
This drug should be coded
