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The tumor site, histology, and behavior combination validity standards for cancer surveillance featured in CPC*Search are based on criteria established by Cancer PathCHART for cases diagnosed January 1, 2024 through December 31, 2024 only. These criteria determine whether cancer registrars can assign codes for a given tumor site, histology, and behavior combination. Search content for cases diagnosed in calendar years 2025 and 2026 will be added in the future.
What is the CPC*Search?
CPC*Search is an interactive webtool that allows cancer registrars and other users to search the 2024 Cancer PathCHART ICD-O-3 Site Morphology Validation List (CPC*SMVL) validity standards by tumor site, histology, and behavior terms and associated codes.
Search results include the expert pathologist-assigned CPC Validity Status of tumor morphology (histology and behavior) by site and organ system, which indicates if specific tumor site-morphology combinations are biologically valid, impossible, or unlikely.
| Validity Status | Site-Type Edit Errors | Coding in Cancer Registry Database |
|---|---|---|
| Valid | Will not generate edit errors | Can be coded |
| Impossible | Will generate an edit error | Cannot be coded |
| Unlikely* | Will generate an edit error | Requires manual override or correction to site and/or morphology to be coded |
* Unlikely tumor site-morphology combinations are included in CPC*Search but were not included in the 2024 Cancer PathCHART ICD-O-3 Site Morphology Validation List (CPC*SMVL).
The CPC Validity Status was derived from an interdisciplinary review by subspecialty matter expert pathologists, registrars, and a biostatistician. Sites with updated standards for 2024 are listed in the table below.
Validity status was assigned to site-morphology combinations using existing 2023 standards as follows.
| 2024 Standard Used for Primary Sites Not Yet Reviewed | 2024 Validity Status |
|---|---|
| 2023 ICD-O-3 SEER Site/Histology Validation List | Valid |
| 2023 Primary Site, Morphology-Imposs ICDO3 (SEER IF38) | Impossible |
| Combinations not included in 2023 Valid or Impossible standards listed above | Unlikely |
Additional information about the 2024 Cancer PathCHART ICD-O-3 Site Morphology Validation List (CPC*SMVL) can be found on the Cancer PathCHART Product Downloads web page.
For determining multiple primaries and/or histology, cancer registrars should refer to the 2024 SEER Solid Tumor Rules or the Hematopoietic and Lymphoid Neoplasm Database.
Cancer registrars should use CPC*Search as a reference to validate site and morphology code combinations assigned for cases diagnosed January 1, 2024, and forward.
CPC*Search Tool
Visit the CPC*Search to search the 2024 Cancer PathCHART ICD-O-3 Site Morphology Validation List (CPC*SMVL).
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