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SEER Inquiry System - Report
Produced: 11/29/2024 5:43 PM
Question 20051046
Inquiry Details
References:
2004 SEER Manual, 1-3
Question:
Reportability/Diagnostic Confirmation--Leukemia: What is the diagnostic confirmation if a positive BCR/ABL result is diagnostic of a malignancy in a patient suspected to have chronic myelogenous leukemia? See Discussion.
Discussion:
Example 1: Peripheral smear states: "No morphologic evidence of chronic myelogenous leukemia."
Addendum: Molecular diagnostic studies showed a positive rearrangement for the BCR gene with the M-bcr (CML type) and of bcr-abl transcript expression".
Example 2: Hematopathology is negative.
Molecular diagnostic study: "fluorescent in situ hybridization (FISH) studies exceeded the limits established by the XXX Cytogenetics Laboratory for this probe set, and thus, demonstrated statistical evidence of BCR/ABL fusion."
Answer:
For cases diagnosed prior to 1/1/2010:
Do not determine reportablility using cytogenetics or molecular studies alone.
Since these are not routine screening tests, we suggest that you query the physician and review the medical record to see what prompted the study and what is being done with the result, but the test alone is not in and of itself sufficient to report the case.
For cases diagnosed 2010 forward, refer to the Hematopoietic and Lymphoid Neoplasm Case Reportability and Coding Manual and the Hematopoietic Database (Hematopoietic DB) provided by SEER on its website to research your question. If those resources do not adequately address your issue, submit a new question to SINQ.
