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SEER Inquiry System - Report
Produced: 05/24/2026 7:18 PM
Question 20100040
Inquiry Details
References:
Heme & Lymph Manual & DB
Question:
Discussion:
Answer:
Updated May 2026
The original answer for this question was to code the primary site to C419 [Bone, NOS] and histology to 9731/3 [solitary plasmacytoma]
In 2021, we received clinical guidance from the WHO 4th edition which stated the presence of two plasmacytomas is multiple myeloma (9732/3), even if the bone marrow is negative or not evaluated. Registrars were not required to go back and review older cases.
This case would be coded as a single primary, 9732/3 and primary site C421.
History:
This SINQ question has been updated to the Hematopoietic & Lymphoid Neoplasm Manual & Database published January 2014.
The original answer below was written based on the rules in 2010
The vertebral lesions are common, as are lesions of the femur. If the patient does not meet the criteria of plasma cell myeloma/multiple myeloma (which is 20% of the leukocyte differential count), do not code the histology to multiple myeloma.
The answers for SINQ questions with 2010 ID numbers were written using the 2010 Heme & Lymph Manual & DB. The instructions for using the 2010 Hematopoietic Database were written for the version of the software in use as of 5/24/2011. The user interface of the web-based 2010 Hematopoietic Database available from the SEER website varies slightly from the 5/24/2011 version in that the web-based version provides all the disease information in one scrollable window.
For cases diagnosed 2010-2011, access the 2010 Hematopoietic Database at http://seer.cancer.gov/tools/heme/. Click on Hematopoietic Project. Click on Hematopoietic and Lymphoid Database. For 2010-2011 diagnoses, click on the "use the 2010 database" label in the upper right corner of the screen. The 2010 Hematopoietic Coding Manual (PDF) button will appear to indicate the correct version of the program is available now for query.
