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SEER Inquiry System - Report
Produced: 10/27/2025 12:26 AM
Question 20240065
Inquiry Details
References:
#1: WHO Class Female Genital Tumors. 5th edition, Ovary
#2: Solid Tumor Rules. Other Sites, 2024 Update, Table 13
Question:
Solid Tumor Rules/Histology--Ovary: What is the histology code for an ovarian primary with a pathology report final diagnosis of “Small-Cell Carcinoma (Hypercalcemic Type), Large-Cell Variant” diagnosed in 2012 (using the Multiple Primaries H rules) and one diagnosed in 2024 (using the Solid Tumor Rules)? See Discussion.
Discussion:
2012 Total abdominal hysterectomy - bilateral salpingo-oophorectomy
Primary Site – Ovary, Right
Histology - Small-Cell Carcinoma (Hypercalcemic Type), Large-Cell Variant
2024 Total abdominal hysterectomy - bilateral salpingo-oophorectomy
Primary Site – Ovary, Left
Histology - Small-Cell Carcinoma (Hypercalcemic Type), Large-Cell Variant
Answer:
Abstract this case as a single primary. Code as 8044/3 (small cell carcinoma, hypercalcemic type) listed in the Other Sites Solid Tumor Rules, Table 13. Small cell carcinoma, large cell variant, is a subtype of small cell carcinoma, hypercalcemic type. This table does not include all possible histologies.
WHO Classification of Female Genital Tumors, 5th edition, states: Small cell carcinoma of the ovary, hypercalcemic type, is rare, accounting for < 1% of ovarian tumors. Small cell carcinomas, hypercalcemic type, are usually large, with a mean size of 15 cm (range: 6–26 cm). Large cells are present (in varying numbers) in half of these tumors, which are designated “small cell carcinoma, large cell subtype” if the large cells are predominant (which is rare).
