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A new Brain/CNS Recode, based on the 2016 World Health Organization Classification of Tumors of the Central Nervous System (CNS), has been added to the SEER databases to allow researchers to analyze brain tumors according to major histological categories.
The information provided in this table is also available to download (XLSX, 20 KB).
| Category | Primary Site | Behavior | Histology | Recode |
|---|---|---|---|---|
| Malignant Brain/ONS | ||||
| 1. Glioma | ||||
| 1.1 Diffuse astrocytoma and anaplastic astrocytoma | 700-729 | 3 | 9400-9401, 9410-9411, 9420 | 01 |
| 1.2 Glioblastoma | 700-729 | 3 | 9440-9442, 9445 | 02 |
| 1.3 Diffuse midline glioma, H3 K27M-mutant | 700-729 | 3 | 9385 | 03 |
| 1.4 Oligodendroglioma | 700-729 | 3 | 9450-9451 | 04 |
| 1.5 Oligoastrocytoma | 700-729 | 3 | 9382 | 05 |
| 1.6 Other astrocytic tumors | 700-729 | 3 | 9421, 9424-9425 | 06 |
| 1.7 Astroblastoma | 700-729 | 3 | 9430 | 07 |
| 1.8 Ependymal tumors | 700-729 | 3 | 9391-9393, 9396 | 08 |
| 1.9 Glioma, unspecified | 700-729 | 3 | 9380 | 09 |
| 1.10 Other | 700-729 | 3 | 9381, 9383-9384, 9394-9395, 9397-9399, 9402-9409, 9412-9419, 9422-9423, 9426-9429, 9431-9439, 9443-9444, 9446-9449, 9452-9460 | 10 |
| 2. Embryonal tumors | 700-729 | 3 | 8963, 9364, 9470-9478, 9490, 9500-9502, 9508 | 11 |
| 3. Meningiomas | 700-729 | 3 | 9530, 9538-9539 | 12 |
| 4. Choroid plexus tumors | 700-729 | 3 | 9390 | 13 |
| 5. Neuronal and mixed neuronal-glial tumors | 700-729 | 3 | 9505, 9509 | 14 |
| 6. Other Malignant Brain/ONS | 700-729 | 3 | Not listed above, excluding 9050–9055, 9140, 9590–9993 | 15 |
| Non-malignant Brain/ONS | ||||
| 1. Meningiomas | 700-729 | 0 | 9530-9534, 9537 | 16 |
| 700-729 | 1 | 9538-9539 | ||
| 2. Tumors of the cranial and paraspinal nerves | 700-729 | 0 | 9540, 9550, 9560, 9563, 9571 | 17 |
| 700-729 | 1 | 9560 | ||
| 3. Ependymal tumors | 700-729 | 1 | 9383, 9394 | 18 |
| 4. Choroid plexus tumors | 700-729 | 0 | 9390 | 19 |
| 700-729 | 1 | 9390 | ||
| 5. Neuronal and mixed neuronal-glial tumors | 700-729 | 0 | 9413, 9492-9493, 9509 | 20 |
| 700-729 | 1 | 8693,9412,9505-9506,9509 | ||
| 6. Mesenchymal, nonmeningothelial tumors | 700-729 | 0 | 8815, 8825, 8830, 8850, 8861, 8880, 8890, 8900, 9120, 9180, 9210, 9220 | 21 |
| 1 | 8815, 8821, 8825, 9161 | |||
| 7. Other astrocytic tumors | 700-729 | 1 | 9384 | 22 |
| 8. Other gliomas | 700-729 | 1 | 9431, 9444 | 23 |
| 9. Other non-malignant Brain/ONS | 700-729 | All other combinations, excluding 9050–9055, 9140, 9590–9993 | 24 | |
| Malignant tumors of the pineal region | 753 | 3 | 9362, 9395 | 25 |
| Non-malignant tumors of the pineal region | 753 | 1 | 9361 | 26 |
| All Other Cancer Types | All other combinations | 27 | ||
* Details of the groupings and how this classification was developed can be found in:
Forjaz G, Barnholtz-Sloan JS, Kruchko C, Siegel R, Negoita S, Ostrom QT, Dickie L, Ruhl J, Van Dyke A, Patil N, Cioffi G, Miller KD, Waite K, Mariotto AB. An updated histology recode for the analysis of primary malignant and nonmalignant brain and other central nervous system tumors in the Surveillance, Epidemiology, and End Results Program. Neurooncol Adv. 2020 Dec 8;3(1):vdaa175. doi: 10.1093/noajnl/vdaa175. [View Article
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