A new Brain/CNS Recode, based on the 2016 World Health Organization Classification of Tumors of the Central Nervous System (CNS), has been added to the SEER databases to allow researchers to analyze brain tumors according to major histological categories.

The information provided in this table is also available to download (XLSX, 20 KB).

Category Primary Site Behavior Histology Recode
Malignant Brain/ONS
1. Glioma
1.1 Diffuse astrocytoma and anaplastic astrocytoma 700-729 3 9400-9401, 9410-9411, 9420 01
1.2 Glioblastoma 700-729 3 9440-9442, 9445 02
1.3 Diffuse mideline glioma, H3 K27M-mutant 700-729 3 9385 03
1.4 Oligodendroglioma 700-729 3 9450-9451 04
1.5 Oligoastrocytoma 700-729 3 9382 05
1.6 Other astrocytic tumors 700-729 3 9421, 9424-9425 06
1.7 Astroblastoma 700-729 3 9430 07
1.8 Ependymal tumors 700-729 3 9391-9393, 9396 08
1.9 Glioma, unspecified 700-729 3 9380 09
1.10 Other 700-729 3 9381, 9383-9384, 9394-9395, 9397-9399, 9402-9409, 9412-9419, 9422-9423, 9426-9429, 9431-9439, 9443-9444, 9446-9449, 9452-9460 10
2. Embryonal tumors 700-729 3 8963, 9364, 9470-9478, 9490, 9500-9502, 9508 11
3. Meningiomas 700-729 3 9530, 9538-9539 12
4. Choroid plexus tumors 700-729 3 9390 13
5. Neuronal and mixed neuronal-glial tumors 700-729 3 9505 14
6. Other Malignant Brain/ONS 700-729 3 Not listed above, excluding 9050–9055, 9140, 9590–9992 15
Non-malignant Brain/ONS
1. Meningiomas 700-729 0 9530-9534, 9537 16
700-729 1 9538-9539
2. Tumors of the cranial and paraspinal nerves 700-729 0 9540,9550,9560,9571 17
700-729 1 9560
3. Ependymal tumors 700-729 1 9383, 9394 18
4. Choroid plexus tumors 700-729 0 9390 19
700-729 1 9390
5. Neuronal and mixed neuronal-glial tumors 700-729 0 9413, 9492-9493 20
700-729 1 8693,9412,9505-9506,9509
6. Mesenchymal, nonmeningothelial tumors 700-729 0 8815, 8825, 8830, 8850, 8861, 8880, 8890, 8900, 9120, 9180, 9210, 9220 21
1 8815, 8821, 8825, 9161
7. Other astrocytic tumors 700-729 1 9384 22
8. Other gliomas 700-729 1 9431, 9444 23
9. Other non-malignant Brain/ONS 700-729 All other combinations, excluding 9050–9055, 9140, 9590–9992 24
Malignant tumors of the pineal region 753 3 9362, 9395 25
Non-malignant tumors of the pineal region 753 1 9361 26
All Other Cancer Types All other combinations 27

* Details of the groupings and how this classification was developed can be found in:
Forjaz G, Barnholtz-Sloan JS, Kruchko C, Siegel R, Negoita S, Ostrom QT, Dickie L, Ruhl J, Van Dyke A, Patil N, Cioffi G, Miller KD, Waite K, Mariotto AB. An updated histology recode for the analysis of primary malignant and nonmalignant brain and other central nervous system tumors in the Surveillance, Epidemiology, and End Results Program. Neurooncol Adv. 2020 Dec 8;3(1):vdaa175. doi: 10.1093/noajnl/vdaa175. [View ArticleExternal Web Site Policy]