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PARP inhibitor
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Definition
A substance that blocks an enzyme in cells called PARP. PARP helps repair DNA when it becomes damaged. DNA damage may be caused by many things, including exposure to UV light, radiation, certain anticancer drugs, or other substances in the environment. In cancer treatment, blocking PARP may help keep cancer cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy.
Types of PARP inhibitors
1. PARP inhibitor AZD2281: A drug used alone or with other drugs to treat adults with certain types of prostate cancer, pancreatic cancer, breast cancer, or ovarian, fallopian tube, or primary peritoneal cancer. It is also being studied in the treatment of other types of cancer. PARP inhibitor AZD2281 blocks an enzyme involved in many cell functions, including the repair of DNA damage. Blocking this enzyme may help keep cancer cells from repairing their damaged DNA, causing them to die. PARP inhibitor AZD2281 is a type of PARP inhibitor. Also called AZD2281, Lynparza, and olaparib.
2. PARP-1 inhibitor ABT-888: A substance being studied in the treatment of breast cancers caused by mutations (changes) in the BRCA1 and BRCA2 genes. It is also being studied in the treatment of other types of cancer. It blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. PARP-1 inhibitor ABT-888 may cause cancer cells to die. It is a type of poly (ADP-ribose) polymerase inhibitor. Also called ABT-888 and veliparib.
3. PARP-1 inhibitor AG014699: A drug used to treat adults with certain types of prostate cancer or ovarian epithelial, fallopian tube, or primary peritoneal cancer. It is also being studied in the treatment of other types of cancer. PARP-1 inhibitor AG014699 blocks an enzyme involved in many cell functions, including the repair of DNA damage. Blocking this enzyme may help keep cancer cells from repairing their damaged DNA, causing them to die. PARP-1 inhibitor AG014699 is a type of PARP inhibitor. Also called AG014699, Rubraca, and rucaparib camsylate.
Types of PARP inhibitors
1. PARP inhibitor AZD2281: A drug used alone or with other drugs to treat adults with certain types of prostate cancer, pancreatic cancer, breast cancer, or ovarian, fallopian tube, or primary peritoneal cancer. It is also being studied in the treatment of other types of cancer. PARP inhibitor AZD2281 blocks an enzyme involved in many cell functions, including the repair of DNA damage. Blocking this enzyme may help keep cancer cells from repairing their damaged DNA, causing them to die. PARP inhibitor AZD2281 is a type of PARP inhibitor. Also called AZD2281, Lynparza, and olaparib.
2. PARP-1 inhibitor ABT-888: A substance being studied in the treatment of breast cancers caused by mutations (changes) in the BRCA1 and BRCA2 genes. It is also being studied in the treatment of other types of cancer. It blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. PARP-1 inhibitor ABT-888 may cause cancer cells to die. It is a type of poly (ADP-ribose) polymerase inhibitor. Also called ABT-888 and veliparib.
3. PARP-1 inhibitor AG014699: A drug used to treat adults with certain types of prostate cancer or ovarian epithelial, fallopian tube, or primary peritoneal cancer. It is also being studied in the treatment of other types of cancer. PARP-1 inhibitor AG014699 blocks an enzyme involved in many cell functions, including the repair of DNA damage. Blocking this enzyme may help keep cancer cells from repairing their damaged DNA, causing them to die. PARP-1 inhibitor AG014699 is a type of PARP inhibitor. Also called AG014699, Rubraca, and rucaparib camsylate.
Resource
Alternate Names
Poly (ADP-ribose) polymerase inhibitor
PARP inhibitor AZD2281
PARP-1 inhibitor ABT-888
PARP-1 inhibitor AG014699
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