Follicular lymphoma, grade 2

ICD-O-2 Morphology

9691/3: Follicular lymphoma, grade 2
Effective 1992 - 2000

ICD-O-3 Morphology

9691/3: Follicular lymphoma, grade 2
Effective 2001 and later


for cases diagnosed 1992 and later

Primary Site(s)

See Module 7
Most common sites of involvement: lymph nodes, spleen, bone marrow (BM), peripheral blood (PB), and Waldeyer ring, skin, duodenum, ocular adnex, breast and testis

Abstractor Notes

Follicular lymphoma, NOS (9690/3) histology is a generic disease description. DCO cases or path report only cases usually stay in this classification. The NOS histology may be the working diagnosis. Further review of the medical record should be done to look for the tests listed as definitive diagnosis.

The more specific follicular lymphomas are:
1. Follicular lymphoma, grade 1 (9695/3)
2. Follicular lymphoma, grade 2 (9691/3)
3. Follicular lymphoma, grade 3 [3A, 3B] (9698/3)

When a more specific diagnosis is identified, the histology should be changed to the more specific neoplasm name and code.

FL is graded according to the proportion of large cells (centroblasts). Studies suggest this histologic grading predicts clinical outcome, with more large cells behaving more aggressively and having a higher likelihood of transformation to diffuse large cell lymphoma.

1) Grade 1-2 (low grade): 0-15 centroblasts per HPF (9691/3)
2) Grade 1: 0-5 centroblasts per HPF (9695/3)
3) Grade 2: 6-15 centroblasts per HPF (9691/3)
4) Grade 3: > 15 centroblasts per HPF (9698/3)
5) Grade 3A: Centrocytes present (9698/3)
6) Grade 3B: Solid sheets of centroblasts (9698/3)

Most patients present with widespread disease, including peripheral and central (abdominal and thoracic) lymphadenopathy and splenomegaly. The BM is involved in 40-70%.

Only 1/3 of patients present with stage I or II at the time of diagnosis.

When any area of diffuse large-B-cell lymphoma (DLBCL) is present in a FL the disease should be reported as diffuse large B-cell lymphoma (9680/3) (See PH rules).

For more information on lymphoma, see the NCI website: or

Diagnostic Confirmation

This histology can be determined by positive histology (including peripheral blood) with or without genetics and/or immunophenotyping. Review the Definitive Diagnostic Methods, Immunophenotyping and Genetics Data sections below, and the instructions in the Hematopoietic Manual for further guidance on assigning Diagnostic confirmation.


See Abstractor Notes

Module Rule


Alternate Names

Diffuse, follicular lymphoma, grade 2
Follicular lymphoma, diffuse, grade 2
Follicular lymphoma, grade 1-2
Grade 2, follicular lymphoma, diffuse
Malignant lymphoma, mixed cell type, follicular [OBS]
Malignant lymphoma, mixed cell type, nodular [OBS]
Malignant lymphoma, mixed lymphocytic-histiocytic, nodular [OBS]
Malignant lymphoma, mixed small cleaved/large cell, follicular [OBS]


Follicular lymphoma (FL) is a neoplasm composed of follicle centre (germinal center) B cells (typically both centrocytes and centroblasts/large transformed cells), which usually has at least a partially follicular pattern. Progression in cytological grade is common during the natural history of the disease.

There are several variants/subtypes of Follicular lymphoma

1) Diffuse variant of follicular lymphoma. See 9690/3.
2) Duodenal-type follicular lymphoma. See 9695/3.
3) Large B-cell lymphoma with IRF4 rearrangement. See 9698/3.
4) Pediatric-type follicular lymphoma. See 9690/3.
5) Testicular follicular lymphoma. See 9698/3.

Definitive Diagnostic Methods

Genetic testing
Histologic confirmation

Genetics Data

CREBBP mutation
EPHA7 mutation
KMT2D (MLL2) mutation
MEF2B mutation
MYC gain
TNFAIP3 (also called A20) deletion, mutation
TNFRSF14 deletion, mutation


BCL2 expression and positive
BCL6 positive
CD5 negative
CD10 expression and positive
CD19 expression
CD20 positive
CD22 expression
CD23 expression
CD43 negative
CD79a expression and positive
GCET1 positive
GCET2 (HGAL) positive
IgD negative
IgM positive
LMO2 positive
PAX5 positive


Hematologic Transplant and/or Endocrine Procedures
Radiation therapy

Transformations from


Corresponding ICD-9 Codes

202.0 Nodular lymphoma

Corresponding ICD-10 Codes

C82.1 Non-Hodgkin lymphoma mixed small cleaved and large cell, follicular

Corresponding ICD-10-CM Codes (U.S. only)

C82.1 Follicular lymphoma grade II (effective October 01, 2015)

Signs and Symptoms

Drenching night sweats
Fever (or no known reason)
Lymphadenopathy (abdominal and thoracic)
Pain in chest, abdomen or bones (for no known reason)
Painless swelling in the lymph nodes in the neck, underarm, groin, or stomach
Skin rash or itchy skin
Weight loss (for no known reason)

Diagnostic Exams

Blood chemistry studies
Cytogenetics studies
CT (CAT) scan
Flow cytometry
Laparoscopy (rarely performed)
Laparotomy (rarely performed)
Lymph node biopsy

Progression and Transformation

25-35% of patients transform to DLBCL

Epidemiology and Mortality

Age: 60 years median age (rare occurrence under 20 years of age)
Incidence: Follicular lymphomas account for 20% of all lymhpomas
Sex: slight female predominance
Survival: 8-15 years median survival, closely related to the extent of the disease at diagnosis


Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Mature B-cell neoplasms
Pages: 266-281

International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020.
Section: ICD-O-3.2 (2020) Morphological Codes

National Cancer Institute
Section: General Information About Adult Non-Hodgkin Lymphoma (NHL)