Mantle cell lymphoma
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Lymphomas has subset of naive pre-germinal center cells, localized in primary follicles or in mantle region of secondary follicles. Majority of cases display unmutated immunoglobulin heavy chain locus.
Morphologic variants of mantle cell lymphoma:
3. Small cell
4. Marginal zone-like
Most patients present in Stage III or IV. Spleen, bone marrow and liver are common metastatic sites.
Patients presenting with peripheral blood, bone marrow and possibly splenic involvement but without adenopathy are reported to have better prognosis.