SEER Hematopoietic and Lymphoid Neoplasm Database

This neoplasm is not reportable.

Name

Transient abnormal myelopoiesis associated with Down syndrome

ICD-O-3 Morphology

9898/1: Transient abnormal myelopiesis

Effective 2010 and later

Reportability

This neoplasm is not reportable

Primary Site(s)

C421

This neoplasm is reportable for primary sites C700-C729, C751-C753 only.

Alternate Names

TAM

Transient abnormal myelopoiesis

Transient myeloproliferative disorder

Definition

Transient abnormal myelopoiesis (TAM) associated with Down syndrome is a unique disorder of newborns with Down syndrome that presents with clinical and morphological findings indistinguishable from those of acute myeloid leukemia. The blasts have morphological and immunological features of megakaryocytic lineage.

Definitive Diagnostic Methods

This data item does not apply

Genetics Data

This data item does not apply

Immunophenotyping

This data item does not apply

Corresponding ICD-9 Codes

238.79 Other lymphatic and hematopoietic tissues

Corresponding ICD-10 Codes

D47.7 Other specified neoplasms of uncertain or unknown behavior of lymphoid, hematopoietic, and related tissue

Corresponding ICD-10-CM Codes (U.S. only)

D47.Z9 Other specified neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue (effective October 01, 2015)

Sources

Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Acute myeloid leukemia and related precursor neoplasms
Pages: 169-170

International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020.
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577

Glossary