Polymorphic post-transplant lymphoproliferative disorder

(This code is effective for cases diagnosed 2021-2024 for CNS sites only.) For cases diagnosed 2010-2021 or 2025+, see 9971/3. This code is not reportable prior to 2010.

For 2021-2024, Polymorphic PTLD (PTLD by itself, no accompanying lymphoma, plasmacytoma, multiple myeloma) is coded as 9971/1 and is only reportable for CNS sites (C700-C729, C751-C753)

Per the IARC/WHO Committee for ICD-O and included in the WHO Tumors of Hematopoietic and Lymphoid Tissues, Revised 4th Ed, Volume 2, PTLD by itself is a /1 starting in ICD-O-3.2. For the US and Canada, 9971/1 will be reportable for years 2021-2024 for CNS sites only.

Starting 1/1/25, PTLD (by itself [polymorphic]), will be reportable for any site and is to be coded as 9971/3.

Please note that ICD-O-3.2 has this as 9971/1; however, the US will be collecting this as 9971/3 starting 1/1/25.

Early PTLD

Florid follicular hyperplasia

Infectious mononucleosis-like lesion

Infectious mononucleosis-like PTLD

Polymorphic B-cell PTLD

Polymorphic post transplant lymphoproliferative disorders

Polymorphic PTLD

P-PTLD

PTLD, NOS

Post-transplant lymphoproliferative disorders (PTLD) are lymphoid or plasmacytic proliferations that develop as a consequence of immunosuppression in a recipient of a solid organ, bone marrow, or stem cell allograft. The early lesions are defined as lymphoid proliferations in an allograft recipient, characterized by architectual preservation of the involved tissue, with preservation of the nodular sinuses or tonsillar crypts, and residual or sometimes floridly reactive follicles in some cases.

238.77 Post-transplant lymphoproliferative disorder (PTLD)

D47.7 Other specified neoplasms of uncertain or unknown behavior of lymphoid, hematopoietic, and related tissue

International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020.
Section: ICD-O-3.2 (2020) Morphological Codes
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