T-cell prolymphocytic leukemia
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Leukemic T-cells are found in the peripheral blood, bone marrow, lymph nodes, spleen, liver and sometimes skin.
Cutaneous involvement consists of perivascular or more diffuse dermal infiltrations without epidermotropism.
The spleen histology shows dense red pulp infiltration which invades the spleen capsule, blood vessels and atrophied white pulp.
There is diffuse lymph node involvement and tends to predominate in the paracortical areas, sometimes with sparing of follicles. Prominent high-endothelial venules may be numerous and are often infiltrated by neoplastic cells.