Search Database ICD-O-3 Code Lists

Name

Myelodysplastic neoplasm post cytotoxic therapy (see 9920/3 for 2010+)

ICD-O-3 Morphology

9987/3: Therapy-related myelodsyplastic syndrome, NOS
Effective 2001 and later

Reportable

2001-2009, 2026 and later; see Abstractor Notes

Primary Site(s)

C421

Coding Manual: Hematopoietic Coding Manual (PDF)

Abstractor Notes

This code may be used for cases diagnosed prior to 1/1/2010.

Prior to 2010, Therapy-related myelodysplastic syndrome was categorized separately. In the 2008 WHO Manual, Therapy-related myeloid leukemia, Therapy-related myelodysplastic syndrome, and Therapy-related myelodysplastic/myeloproliferative neoplasms are grouped under 9920/3. This grouping reflects the fact that each of these neoplasms are caused by previous therapy and they are grouped in this manner to facilitate analysis.
For further information on the coding and abstracting of this neoplasm, see 9920/3.

Be aware that cases diagnosed prior to 2010 will be coded 9987/3.

Diagnostic Confirmation

None

Module Rule

None

Alternate Names

Therapy-related myelodysplastic syndrome (t-MDS), NOS (see 9920/3 for 2010+)
Therapy-related myelodysplastic syndrome, alkylating agent related (see 9920/3 for 2010+)
Therapy-related myelodysplastic syndrome, epipodophyllotoxin-related (see 9920/3 for 2010+)

Definition

Bone marrow failure that develops after treatment with chemotherapy or radiation therapy. There is no predominant cell type that is dysplastic, and the marrow aspirate is often inadequate to review for dysplasia, as the marrow is often hypocellular with fibrosis.

Therapy-related MDS arise as a result of cytotoxic chemotherapy and/or radiation therapy.

Definitive Diagnostic Methods

None

Genetics Data

None

Immunophenotyping

None

Treatments

Chemotherapy

Transformations to

There are no known transformations

Transformations from

There are no known transformations

Same Primaries

Corresponding ICD-10 Codes (Cause of Death codes only)

D46.7 Other myelodysplastic syndromes

Corresponding ICD-10-CM Codes (U.S. only)

D46.Z Other myelodysplastic syndromes (effective October 01, 2015)

Signs and Symptoms

Bone marrow failure
Cytopenia
Easy bruising or bleeding
Fatigue
Fever
Petechiae
Shortness of breath
Weakness
Weight loss or loss of appetite

Diagnostic Exams

Bone marrow biopsy or aspiration
CT (CAT) Scan
Cytogenetic analysis
Flow cytometry
Immunophenotyping
Lumbar puncture
Molecular analysis
Peripheral blood smear
Physical exam and history

Progression and Transformation

None

Epidemiology and Mortality

None

Sources

International Classification of Diseases for Oncology, 3rd edition (including revisions). Geneva: World Health Organization, 2001, 2011, 2020.
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577
Glossary