Myeloid leukemia, NOS

ICD-O-1 Morphology
9860/3: Myeloid leukemia, NOS
Effective 1978 - 1991
ICD-O-2 Morphology
9860/3: Myeloid leukemia, NOS
Effective 1992 - 2000
ICD-O-3 Morphology
9860/3: Myeloid leukemia, NOS
Effective 2001 and later
for cases diagnosed 1978 and later
Primary Site(s)
Primary site must be bone marrow (C421)

Not Applicable
Module Rule
Alternate Names
Aleukemic granulocytic leukemia [OBS]
Aleukemic monocytic leukemia [OBS]
Chronic monocytic leukemia [OBS]
Granulocytic leukemia, NOS
Monocytic leukemia
Myelocytic leukemia, NOS
Myelogenous leukemia, NOS [OBS] see code 9875/3
Myelomonocytic leukemia [OBS] see codes 9945/3 or 9967/3
Non-lymphocytic leukemia, NOS
Subacute granulocytic leukemia [OBS]
Subacute monocytic leukemia [OBS]
Subacute myelogenous leukemia [OBS]
Subacute myeloid leukemia [OBS]
General term for non-specific myeloid leukemia (unknown if chronic or acute) in which cell typing has not been done, or the information is not available.
Abstractor Notes
Myeloid leukemia, NOS is a generic disease description. DCO cases or path report only cases may stay in this classification.

In most cases, NOS histology is only the provisional diagnosis; the physician will run further diagnostic procedures and look for various clinical presentations to identify a more specific disease. Further review of the medical record should be done to look for the tests listed as definitive diagnosis. If no information is found in the medical record, follow-back to the attending physician should be done.

More specific myeloid leukemias include:
1. Acute myeloid leukemia, NOS (9861/3)
2. Acute myeloid leukemia (megakaryoblastic) with t(1;22)(p13;q13);RBM15-MKL1 (9911/3)
3. Acute myeloid leukemia with inv(3)(q21;q26.2) or t(3;3)(q21;q26;2); RPN1-EVI1 9869/3)
4. Acute myeloid leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22), CBFB/MYH11 (9871/3)
5. Acute myeloid leukemia with maturation (9874/3)
6. Acute myeloid leukemia with minimal differentiation (9872/3)
7. Acute myeloid leukemia with mutated CEBPA (9861/3)
8. Acute myeloid leukemia with mutated NPM1 (9861/3)
9. Acute myeloid leukemia with myelodysplasia-related changes (9895/3)
10. Acute myeloid leukemia with t(6;9)(p23;q34); DEK-NUP214 (9865/3)
11. Acute myeloid leukemia with t(8;21)(q22;q22); RUNX1-RUNX1T1 (9896/3)
12. Acute myeloid leukemia with t(9;11)(p22;q23); MLLT3-MLL (9897/3)
13. Acute myeloid leukemia without maturation (9873/3)
14. Myeloid leukemia associated with Down syndrome (9898/3)
15. Myeloid neoplasm with PDGFRB arrangement (9966/3)

When a more specific diagnosis is identified, the histology should be changed to the more specific neoplasm name and code. See the histology tables for more information on NOS and more specific histologies.
Definitive Diagnostic Methods
Bone marrow biopsy
Peripheral blood smear
Genetics Data
Transformations to
There are no known transformations
Transformations from
There are no known transformations
Same Primaries
Corresponding ICD-9 Codes
205.9 Unspecified myeloid leukemia
Corresponding ICD-10 Codes
C92.9 Myeloid leukemia, unspecified
Corresponding ICD-10-CM Codes (U.S. only)
C92.9 Myeloid leukemia, unspecified (effective October 01, 2015)
Signs and Symptoms
Diagnostic Exams
Progression and Transformation
Epidemiology and Mortality