Name

ICD-O-1 Morphology

9860/3: Myeloid leukemia, NOS
9862/3: Subacute myeloid leukemia
9890/3: Monocytic leukemia
9892/3: Subacute monocytic leukemia
9894/3: Aleukemic monocytic leukemia
Effective 1978 - 1991

ICD-O-2 Morphology

9860/3: Myeloid leukemia, NOS
9862/3: Subacute myeloid leukemia
9890/3: Monocytic leukemia
9892/3: Subacute monocytic leukemia
9894/3: Aleukemic monocytic leukemia
Effective 1992 - 2000

ICD-O-3 Morphology

9860/3: Myeloid leukemia, NOS
Effective 2001 and later

Reportable

for cases diagnosed 1978 and later

Primary Site(s)

C421
Primary site must be bone marrow (C421)

Grade

Not Applicable

Module Rule

None

Alternate Names

Aleukemic granulocytic leukemia [OBS]
Aleukemic monocytic leukemia [OBS]
Chronic monocytic leukemia [OBS]
Granulocytic leukemia, NOS
Monocytic leukemia, NOS
Myelocytic leukemia, NOS
Myelogenous leukemia, NOS [OBS] see code 9875/3
Myelomonocytic leukemia [OBS] see codes 9945/3 or 9967/3
Non-lymphocytic leukemia, NOS
Subacute granulocytic leukemia [OBS]
Subacute monocytic leukemia [OBS]
Subacute myelogenous leukemia [OBS]
Subacute myeloid leukemia [OBS]

Definition

General term for non-specific myeloid leukemia (unknown if chronic or acute) in which cell typing has not been done, or the information is not available.

Abstractor Notes

Myeloid leukemia, NOS is a generic neoplasm description. DCO cases or path report only cases may stay in this classification.

In most cases, NOS histology is only the provisional diagnosis; the physician will run further diagnostic procedures and look for various clinical presentations to identify a more specific neoplasm. Further review of the medical record should be done to look for the tests listed as definitive diagnosis. If no information is found in the medical record, follow-back to the attending physician should be done.

More specific myeloid leukemias include:
1. Acute myeloid leukemia, NOS (9861/3)
2. Acute myeloid leukemia (megakaryoblastic) with t(1;22)(p13;q13);RBM15-MKL1 (9911/3)
3. Acute myeloid leukemia with inv(3)(q21;q26.2) or t(3;3)(q21;q26;2); RPN1-EVI1 9869/3)
4. Acute myeloid leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22), CBFB/MYH11 (9871/3)
5. Acute myeloid leukemia with maturation (9874/3)
6. Acute myeloid leukemia with minimal differentiation (9872/3)
7. Acute myeloid leukemia with mutated CEBPA (9861/3)
8. Acute myeloid leukemia with mutated NPM1 (9861/3)
9. Acute myeloid leukemia with myelodysplasia-related changes (9895/3)
10. Acute myeloid leukemia with t(6;9)(p23;q34); DEK-NUP214 (9865/3)
11. Acute myeloid leukemia with t(8;21)(q22;q22); RUNX1-RUNX1T1 (9896/3)
12. Acute myeloid leukemia with t(9;11)(p22;q23); MLLT3-MLL (9897/3)
13. Acute myeloid leukemia without maturation (9873/3)
14. Myeloid leukemia associated with Down syndrome (9898/3)
15. Myeloid neoplasm with PDGFRB arrangement (9966/3)

When a more specific diagnosis is identified, the histology should be changed to the more specific neoplasm name and code. See the histology tables for more information on NOS and more specific histologies.

Definitive Diagnostic Methods

Bone marrow biopsy
Peripheral blood smear

Genetics Data

None

Immunophenotyping

None

Treatments

None

Transformations to

There are no known transformations

Transformations from

There are no known transformations

Same Primaries

Corresponding ICD-9 Codes

205.9 Unspecified myeloid leukemia
206.2 Subacute monocytic leukemia
206.9 Unspecified monocytic leukemia

Corresponding ICD-10 Codes

C92.9 Myeloid leukemia, unspecified
C93.7 Other monocytic leukemia
C93.9 Monocytic leukemia, unspecified

Corresponding ICD-10-CM Codes (U.S. only)

C92.9 Myeloid leukemia, unspecified (effective October 01, 2015)
C93.9 Monocytic leukemia, unspecified (effective October 01, 2015)
C93.Z Other monocytic leukemia (effective October 01, 2015)

Signs and Symptoms

None

Diagnostic Exams

None

Progression and Transformation

None

Epidemiology and Mortality

None

Sources

International Classification of Diseases for Oncology, Third Edition, First Revision. Geneva: World Health Organization, 2013.
Section: ICD-O-3.1 (2011) Morphological Codes
Pages: http://codes.iarc.fr/codegroup/2
Glossary