Name

Acute myeloid leukemia with minimal differentiation

ICD-O-2 Morphology

9869/3: FAB M0; Acute myeloblastic leukemia
Effective 1995 - 2000

ICD-O-3 Morphology

9872/3: Acute myeloid leukemia with minimal differentiation
Effective 2001 and later

Reportable

for cases diagnosed 1995 and later

Primary Site(s)

C421
Primary site must be bone marrow (C421)

Grade

Not Applicable

Module Rule

See abstractor notes

Alternate Names

Acute myeloblastic leukemia, minimally differentiated
Acute myeloid leukemia, M0
FAB M0

Definition

Acute myeloid leukemia (AML) with minimal differentiation is an AML with no morphological or cytochemical evidence of myeloid differentiation. The myeloid nature of the blasts is demonstrated by immunological markers, which are essential for distinguishing this entity from lymphoblastic leukemia.

Abstractor Notes

If the leukemia occurs before or simultaneously with Myeloid Sarcoma (9930/3), see M3 and Module 5:PH10.

Definitive Diagnostic Methods

Genetic testing
Immunophenotyping

Genetics Data

FLT3
Gain of chromome 9
Loss of chromosome 5 [del(5q)] and 7 [del(7q)]
RUNX1(also called AML1)

Immunophenotyping

CD3 negative
CD13 expression
CD22 negative
CD33 expression
CD34 expression
CD38 expression
CD79a negative
HLA-DR expression
KIT (CD117) expression
TdT positive

Treatments

Chemotherapy
Hematologic Transplant and/or Endocrine Procedures

Transformations to

None

Corresponding ICD-9 Codes

205.0 Acute myeloid leukemia

Corresponding ICD-10 Codes

C92.0 Acute myeloid leukemia

Corresponding ICD-10-CM Codes (U.S. only)

C92.0 Acute myeloblastic leukemia (effective October 01, 2015)

Signs and Symptoms

Easy bruising or bleeding
Shortness of breath
Weakness
Weight loss or loss of appetite

Progression and Transformation

None

Epidemiology and Mortality

Age: most common in either infants or older adults
Incidence: <5% of all AML cases

Sources

Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Acute myeloid leukemia and related precursor neoplasms
Pages: 156-157

International Classification of Diseases for Oncology, Third Edition, First Revision. Geneva: World Health Organization, 2013.
Section: ICD-O-3.1 (2011) Morphological Codes
Pages: http://codes.iarc.fr/codegroup/2

National Cancer Institute
Section: General Information About Acute Myeloid Leukemia
Pages: https://www.cancer.gov/types/leukemia/hp/adult-aml-treatment-pdq
Glossary