Myelodysplastic syndrome associated with isolated del(5q)

Myelodysplastic syndrome associated with isolated del(5q)
ICD-O-3 Morphology
9986/3: Myelodysplastic syndrome associated with isolated del (5q)
Effective 2001 and later
for cases diagnosed 2001 and later
Primary Site(s)
Primary site must be bone marrow (C421)

Not Applicable
Module Rule
Alternate Names
MDS with 5q deletion
Myelodysplastic syndrome with 5q deletion (5q-syndrome)
Bone marrow dysplasia showing refractory macrocytic anemia with oval macrocytes and nonlobulated megakaryocytes. 75% of patients have increased cellularity of marrow. One third of patients have chromosomal abnormality that consists of deletion of the long arm of chromosome 5 (5q). Marrow blasts <5%.
Platelet count normal to elevated
No Auer rods
Normal to increased megakaryocytes
Abstractor Notes
MDS with associated del(5q) is an MDS involves that blood and bone marrow.

For MDS diseases (9980, 9982, 9983, 9985, 9986, 9989, 9991, 9992), abstracting each of the subtypes would result in over-counting of the diseases.
1. Code only the first subtype that is diagnosed.
2. Do not change the histology code or create a new abstract for any subsequent specific MDS subtypes

Recently the thalidomide analog lenalidomide has been shown to benefit MDS patients. Transfusion independence was achieved in two-thirds of patients.
Definitive Diagnostic Methods
Bone marrow biopsy
Genetic testing
Genetics Data
Deletion between bands q31 and q33 on chromosome 5
Bone marrow transplant
Stem cell transplant
Transformations from
Corresponding ICD-9 Codes
238.74 Myelodysplastic syndrome with 5q deletion
Corresponding ICD-10 Codes
D46.7 Other myelodysplastic syndromes
Corresponding ICD-10-CM Codes (U.S. only)
D46.C Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality (effective October 01, 2015)
Signs and Symptoms
Easy bruising or bleeding
Petechiae (flat, pinpoint spots under the skin caused by bleeding)
Shortness of breath
Skin paler than usual
Weakness or feeling tired
Progression and Transformation
<10% of cases transform to AML
Epidemiology and Mortality
Age: 67 years median age
Sex: female predominance