Name

Acute myeloid leukemia with maturation

ICD-O-2 Morphology

9865/3: FAB M2, NOS; Acute myelocytic leukemia with maturation
Effective 1995 - 2000

ICD-O-3 Morphology

9874/3: Acute myeloid leukemia with maturation
Effective 2001 and later

Reportable

for cases diagnosed 1995 and later

Primary Site(s)

C421
Primary site must be bone marrow (C421)

Grade

Not Applicable

Module Rule

See abstractor notes

Alternate Names

Acute myeloid leukemia, M2
AML with maturation
FAB M2, NOS

Definition

Acute myeloid leukemia (AML) with maturation is characterized by the presence of greater than or equal to 20% blasts in the bone marrow or peripheral blood and evidence of maturation (with greater than or equal to 10% of maturing cells of granulocytic lineage) in the bone marrow; cells of monocyte lineage constitute < 20% of bone marrow cells.

Abstractor Notes

The provisional diagnosis during workup may include RA with excess blasts, AML without maturation, AML with maturation, and acute myelomonocytic leukemia.

The immunophenotyping information listed below is useful only because it shows those factors that are positive for all myeloid leukemias. The bone marrow only identifies a myeloid neoplasm. Neither the bone marrow biopsy nor the immunophenotyping provide a definitive diagnosis of AML with maturation.

If the leukemia occurs before or simultaneously with Myeloid Sarcoma (9930/3), see M3 and Module 5:PH10.

Definitive Diagnostic Methods

Clinical diagnosis
Immunophenotyping

Genetics Data

None

Immunophenotyping

CD7 expression
CD11b expression
CD13 expression
CD14 absent
CD15 expression
CD33 expression
CD34 expression
CD36 absent
CD64 absent
CD65 expression
HLA-DR expression
KIT (CD117) expression

Treatments

Chemotherapy
Hematologic Transplant and/or Endocrine Procedures

Transformations to

None

Corresponding ICD-9 Codes

205.0 Acute myeloid leukemia

Corresponding ICD-10 Codes

C92.0 Acute myeloid leukemia

Corresponding ICD-10-CM Codes (U.S. only)

C92.0 Acute myeloblastic leukemia (effective October 01, 2015)

Signs and Symptoms

Easy bruising or bleeding
Shortness of breath
Variable white blood count
Weakness
Weight loss or loss of appetite

Progression and Transformation

None

Epidemiology and Mortality

Age: all age groups with 20% less than 25 years and 40% greater than 60
Incidence: 10% of all AML cases

Sources

Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Acute myeloid leukemia and related precursor neoplasms
Pages: 158-159

International Classification of Diseases for Oncology, Third Edition, First Revision. Geneva: World Health Organization, 2013.
Section: ICD-O-3.1 (2011) Morphological Codes
Pages: http://codes.iarc.fr/codegroup/2

National Cancer Institute
Section: General Information About Acute Myeloid Leukemia
Pages: https://www.cancer.gov/types/leukemia/hp/adult-aml-treatment-pdq
Glossary