Chronic myelogenous leukemia, BCR-ABL1 positive
Help me code for diagnosis year :
The bone marrow is examined by chromosome and/or molecular techniques for the Philadelphia chromosome, which is required for a definitive diagnosis of CML.
The Philadelphia chromosome is identified in the bone marrow by FISH analysis. Polymerase chain reaction (PCR) is a very specialized molecular blood test that can detect the BCR-ABL1 gene from a blood sample or bone marrow.
CML has four phases:
1. Accelerated phase - can last weeks to months.
2. Chronic phase - involvement is usually limited to blood, bone marrow and spleen, although the liver may be infiltrated.
3. Blastic phase - lymph nodes and tissue may be involved. The blastic phase is a disease progression from the chronic phase. The disease; however, remains the same histology: Chronic myelogenous leukemia.
4. Terminal phase - last phase and survival is usually only weeks or months.
Tyrosine kinase inhibitor; high-dose chemotherapy with donor cell transplant; BRM (interferon) with or without chemotherapy. May also have single or multi-agent chemotherapy and splenectomy.
Donor stem cell transplant; tyrosine kinase inhibitor; BRM (interferon) with or without chemotherapy.
Tyrosine kinase inhibitor; single or multi-drug chemotherapy; donor stem cell transplant.
Aspirin was previously documented as treatment for this disease. This was found to be incorrect. Treatment has been updated based on the NCI website (updated 6/12/15)