Name

Acute myeloid leukemia without maturation

ICD-O-3 Morphology

9873/3: Acute myeloid leukemia without maturation
Effective 2001 and later

Reportable

for cases diagnosed 2001 and later

Primary Site(s)

C421
Primary site must be bone marrow (C421)

Grade

Not Applicable

Module Rule

See abstractor notes

Alternate Names

Acute myeloblastic leukemia without maturation
Acute myeloid leukemia, M1
AML without maturation
FAB M1

Definition

Acute myeloid leukemia (AML) without maturation is characterized by a high percentage of bone marrow blasts without significant evidence of maturation to more mature neutrophils, maturing cells of the granulocytic lineage constitute < 10% of the nucleated bone marrow cells.

Abstractor Notes

If the leukemia occurs before or simultaneously with Myeloid Sarcoma (9930/3), see M3 and Module 5:PH10

Definitive Diagnostic Methods

Bone marrow biopsy
Immunophenotyping

Genetics Data

None

Immunophenotyping

CD3 negative
CD7 expression
CD11b expression
CD13 positive
CD22 negative
CD33 positive
CD34 positive
CD79a negative
KIT (CD117) positive
HLA-DR positive
MPO expression

Treatments

Chemotherapy

Transformations to

None

Corresponding ICD-9 Codes

205.0 Acute myeloid leukemia

Corresponding ICD-10 Codes

C92.0 Acute myeloid leukemia

Corresponding ICD-10-CM Codes (U.S. only)

C92.0 Acute myeloblastic leukemia (effective October 01, 2015)

Signs and Symptoms

Easy bruising or bleeding
Shortness of breath
Weakness
Weight loss or loss of appetite

Progression and Transformation

None

Epidemiology and Mortality

Age: 46 years median age
Incidence: 5-10% of all AML cases

Sources

Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Acute myeloid leukemia and related precursor neoplasms
Pages: 157-158

International Classification of Diseases for Oncology, Third Edition, First Revision. Geneva: World Health Organization, 2013.
Section: ICD-O-3.1 (2011) Morphological Codes
Pages: http://codes.iarc.fr/codegroup/2

National Cancer Institute
Section: General Information About Acute Myeloid Leukemia
Pages: https://www.cancer.gov/types/leukemia/hp/adult-aml-treatment-pdq
Glossary