Acute myeloid leukemia with t(6;9)(p23;q34.1); DEK-NUP214

ICD-O-3 Morphology

9865/3: Acute myeloid leukemia with t(6;9)(p23;q34);DEK-NUP214
Effective 2010 and later


for cases diagnosed 2010 and later

Primary Site(s)

Primary site must be bone marrow (C421)

Abstractor Notes

(This code is effective for cases diagnosed 2010 and later. For cases diagnosed prior to 2010, see code 9861/3.)

This AML has a generally poor prognosis. Elevated white blood cell counts are most predictive of shorter overall survival and increased BM blasts are associated with shorter free survival. Very limited data available regarding treatment or survival.

In adults the WBC is generally lower than other AML types. The BM may have morphologic and cytochemical features of any FAB subtype of AML other than acute promyelocytic leukemia and acute megakaryoblastic leukemia.

If the leukemia occurs before or simultaneously with Myeloid Sarcoma (9930/3), see M3 and Module 5:PH10.

Diagnostic Confirmation

This AML is part of the "AML with recurrent genetic abnormalities" group. Since this AML is diagnosed based on genetics, diagnostic confirmation will always be 3.


Not Applicable

Module Rule

See abstractor notes

Alternate Names

Acute myeloid leukemia with t(6;9)(p23;q34); DEK-NUP214


Acute myeloid leukemia with t(6;9)(p23;q34.1) resulting in DEK-NUP214 is an AML with greater than or equal to 20% peripheral blood or bone marrow blasts with or without monocytic features. It is often associated with basophilia and multilineage dysplasia.

Definitive Diagnostic Methods

Bone marrow biopsy
Genetic testing

Genetics Data

NUP214 (also called CAN) on chromosome 9


CD9 expression
CD13 expression
CD15 expression
CD33 expression and positive
CD34 expression
CD38 expression and positive
CD64 expression
CD123 positive
HLA-DR negative
KIT (CD117)
MPO expression


Hematologic Transplant and/or Endocrine Procedures

Transformations to


Corresponding ICD-9 Codes

205.0 Acute myeloid leukemia

Corresponding ICD-10 Codes

C92.0 Acute myeloid leukemia

Corresponding ICD-10-CM Codes (U.S. only)

C92.0 Acute myeloblastic leukemia (effective October 01, 2015)

Signs and Symptoms

Easy bruising or bleeding
Shortness of breath
Weight loss or loss of appetite

Diagnostic Exams

CT (CAT) scan
Cytogenetic analysis
Lumbar puncture
Peripheral blood smear
Physical exam and history
Reverse transcription-polymerase chain reaction test (RT-PCR)

Progression and Transformation

Elevated white blood cell counts associated with shorter overall survival
Increased bone marrow blasts associated shorter disease-free survival

Epidemiology and Mortality

Age: 13 years median age in children, 35 years median age in adults
Incidence: 0.7-1.8% of AML cases
Survival: poor prognosis for both children and adults


Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Acute myeloid leukemia and related precursor neoplasms
Pages: 137-138

International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020.
Section: ICD-O-3.2 (2020) Morphological Codes

National Cancer Institute
Section: General Information About Acute Myeloid Leukemia