Search Database ICD-O-3 Code Lists

Name

Chronic myeloid leukemia (CML), NOS (ICD-O-4: 98630/3)

ICD-O-3 Morphology

9863/3: Chronic myeloid leukemia, NOS
Effective 2001 and later

Reportable

for cases diagnosed 1978 and later

Primary Site(s)

C421

Coding Manual: Hematopoietic Coding Manual (PDF)

Abstractor Notes

This code is not included in the WHO 5th edition Blue Book. (See Appendix B in the Hematopoietic Manual, Table B23)

Per the WHO Blue Book, a diagnosis of Chronic myeloid leukemia with the BCR::ABL1 unspecified, code 9875/3 should be used instead of 9863/3. This is because most of the CML cases are BCR::ABL1 positive. CML BCR::ABL1 negative cases are rare and have additional testing and will be documented clearly.

Chronic myeloid leukemia, BCR::ABL1 negative is 9876/3.

So, do not use 9863/3 if the diagnosis is Chronic Myeloid Leukemia and there is no BCR::ABL1 status. Code 9875/3 to indicate CML, BCR::ABL1.

Diagnostic Confirmation

This neoplasm can be diagnosed clinically (diagnostic confirmation codes 5, 6, 8) or histologically WITHOUT positive immunophenotyping or genetics (diagnostic confirmation codes 1, 2, 4)

Module Rule

None

Alternate Names

Chronic myelocytic leukemia, NOS (ICD-O-4: 98630/3)

Definition

No delineation of translocation, BCR-ABL1, or Phil chromosome noted to qualify for ICD-O-3 9863.

Specific term as defined by WHO, codes as 9875/3 and indicates the process has Ph+, BCR-ABL1 fusion and/or t(9;22)(q34;q11) demonstrated, as defined by ICD-O-3 for 9875 as well. Presumably myelogenous leukemia without genetic studies done would be coded to 9863.

Definitive Diagnostic Methods

Clinical diagnosis
Histologic confirmation

Genetics Data

None

Immunophenotyping

None

Treatments

Chemotherapy
Hematologic Transplant and/or Endocrine Procedures
Immunotherapy

Transformations to

There are no known transformations

Transformations from

There are no known transformations

Same Primaries

Corresponding ICD-10 Codes (Cause of Death codes only)

C92.1 Chronic myeloid leukemia
C95.1 Chronic leukemia of unspecified cell type

Corresponding ICD-10-CM Codes (U.S. only)

C95.1 Chronic leukemia of unspecified cell type (effective October 01, 2015 - September 30, 2024)
C95.10 Chronic leukemia of unspecified cell type not having achieved remission (effective October 01, 2024)
C95.11 Chronic leukemia of unspecified cell type, in remission (effective October 01, 2024)
C95.12 Chronic leukemia of unspecified cell type, in relapse (effective October 01, 2024)

Signs and Symptoms

Bone or joint pain
Easy bruising or bleeding
Eczema-like skin rash
Fatigue
Fever
Night sweats
Pain or feeling of fullness below the ribs
Painless lumps
Petechiae
Shortness of breath
Weakness

Diagnostic Exams

Bone marrow aspiration and biopsy
CT (CAT) scan
Cytogenetic analysis
Flow cytometry
Immunophenotyping
Lumbar puncture
Molecular analysis
Peripheral blood smear
Physical exam and history

Progression and Transformation

None

Epidemiology and Mortality

None

Sources

International Classification of Diseases for Oncology, 3rd edition (including revisions). Geneva: World Health Organization, 2001, 2011, 2020.
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577

PDQ® Adult Treatment Editorial Board. PDQ Chronic Myeloid Leukemia Treatment. Bethesda, MD: National Cancer Institute. Updated <12/13/2024>. Available at: https://www.cancer.gov/types/leukemia/hp/cml-treatment-pdq. Accessed <02/06/2025>. [PMID: 26389354]
Section: Chronic Myeloid Leukemia Treatment (PDQ®)–Health Professional Version
Pages: https://www.cancer.gov/types/leukemia/hp/cml-treatment-pdq
Glossary