Name
Acute megakaryoblastic leukemia
Reportable
for cases diagnosed
1978 and later
Primary Site(s)
C421
Primary site must be bone marrow (C421)
Coding Manual:
Hematopoietic Coding Manual (PDF)
Abstractor Notes
If the leukemia occurs before or simultaneously with Myeloid Sarcoma (9930/3), see M3 and Module 5:PH10
Diagnostic Confirmation
This histology can be determined by positive histology (including peripheral blood) with or without genetics and/or immunophenotyping. Review the Definitive Diagnostic Methods, Immunophenotyping and Genetics Data sections below, and the instructions in the Hematopoietic Manual for further guidance on assigning Diagnostic confirmation.
Grade
Not Applicable
Module Rule
None
Alternate Names
Definition
Acute megakaryoblastic leukemia is an acute leukemia with greater than or equal to 20% blasts, of which greater than or equal to 50% are of megakaryocyte lineage.
Definitive Diagnostic Methods
Bone marrow biopsy
Immunophenotyping
Peripheral blood smear
Genetics Data
None
Immunophenotyping
CD7+ (expression/positive)
CD13+ (expression/positive)
CD33+ (expression/positive)
CD34+ ((expression/positive)
CD36+ (expression/positive)
CD41 (glycoprotein IIb/IIIa)+ (expression/positive)
CD42b (glycoprotein Ib)+ (expression/positive)
CD45- (no expression/negative)
CD61 (glycoprotein IIIa)+ (expression/positive)
HLA-DR- (not expression/negative)
MPO- (no expression/negative)
Treatments
Chemotherapy
Hematologic Transplant and/or Endocrine Procedures
Radiation therapy
Transformations to
None
Transformations from
Same Primaries
Corresponding ICD-9 Codes
207.2 Megakaryocytic leukemia
Corresponding ICD-10 Codes
C94.2 Acute megakaryoblastic leukemia
Corresponding ICD-10-CM Codes (U.S. only)
C94.2 Acute megakaryoblastic leukemia (effective October 01, 2015)
Signs and Symptoms
Anemia
Asthenia
Cytopenia
Easy bruising or bleeding
Fever
Hepatosplenomegaly
Severe infections (due to decreased neutrophils)
Thrombocytopenia
Thrombocytosis
Diagnostic Exams
Blood chemistry studies
CT (CAT) scan
Cytogenetic analysis
Immunophenotyping
Lumbar puncture
Peripheral blood smear
Reverse transcription-polymerase chain reaction (RT-PCR)
Progression and Transformation
None
Epidemiology and Mortality
Sources
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Acute myeloid leukemia and related precursor neoplasms
Pages: 162-164
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Acute myeloid leukemia and related precursor neoplasms
Pages: 162-164
International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020.
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577
National Cancer Institute
Section: General Information About Acute Myeloid Leukemia
Pages: https://www.cancer.gov/types/leukemia/hp/adult-aml-treatment-pdq
Section: General Information About Acute Myeloid Leukemia
Pages: https://www.cancer.gov/types/leukemia/hp/adult-aml-treatment-pdq