Solitary plasmacytoma of bone

ICD-O-1 Morphology

9731/3: Solitary plasmactyoma of bone
Effective 1978 - 1991

ICD-O-2 Morphology

9731/3: Solitary plasmactyoma of bone
Effective 1992 - 2000

ICD-O-3 Morphology

9731/3: Solitary plasmactyoma of bone
Effective 2001 and later


for cases diagnosed 1978 and later

Primary Site(s)

Primary site must be bone (C400-C419). The most common bones involved are the vertebrae. The thoracic vertebrae are more commonly involved then the cervical or lumbar. Other common bones include the ribs, skull, pelvis, femur, clavical, and scapula.


Not Applicable

Module Rule

Module 2: PH3, PH4

Alternate Names

Osseous (medullary) plasmacytoma
Plasmacytoma, NOS (occurring in bone)
Solitary myeloma
Solitary osseous (medullary) plasmacytoma
Solitary plasmacytoma (occurring in bone)


Solitary plasmacytomas are single localized tumors consisting of monoclonal plasma cells with no clinical features of plasma cell myeloma (PCM)(see 9732/3) and no physical or radiological evidence of additional plasma cell tumors.

Abstractor Notes

This is a localized solitary tumor in the bone consisting of monoclonal plasma cells. Complete skeletal radiographs (preferably MRI) show no other lesions. If additional lesions are found on MRI or CT (or other radiological surveys), this is diagnostic of plasma cell myeloma (see 9732/3).

There is no evidence of bone marrow plasmacytosis other than the solitary lesion. Vertebral lesions may be associated with symptomatic cord compression.

Patient presents with bone pain at the site of the lesion or with a pathological fracture. Soft tissue extension may produce a palpable mass.
An M-protein is found in the serum or urine in 24-72% of patients.

Local control is achieved by radiotherapy. Plasma cells are usually easily recognizable in tissue specimens. Even when the diagnosis is apparent, determination of light chain type is suggested.

Plasma cell neoplasm was previously included as an alternate name for plasmacytoma. The phrase "plasma cell neoplasm" is an umbrella term used for many diseases, some of which are not reportable. If the only diagnosis is "plasma cell neoplasm," then do not report this case. If it is "plasma cell neoplasm" consistent with a plasmacytoma or multiple myeloma, then the case would be reportable.

If the diagnosis is "plasmacytoma" and there is no additional information to indicate if it's a plasmacytoma of the bone or an extramedullary plasmacytoma, default to plasmacytoma of the bone and assign histology, 9731/3.

Definitive Diagnostic Methods

Genetic testing
Histologic confirmation

Genetics Data

Ig clonal rearrangements, complex karyotypes with multiple chromosomal gains/losses; also translocations, deletions, mutations


Negative: CD19
Positive: CD38, CD56, CD79a, CD138, Cytoplasmic Ig, VS38c
Surface Ig lacking


Radiation therapy

Transformations to

Transformations from


Same Primaries

Corresponding ICD-9 Codes

203.8 Other immunoproliferative neoplasms

Corresponding ICD-10 Codes

C90.2 Plasmacytoma, extramedullary

Corresponding ICD-10-CM Codes (U.S. only)

C90.3 Solitary plasmacytoma (effective October 01, 2015)

Signs and Symptoms

Bone pain at site of lesion
M-protein found in serum or urine
Palpable mass due to soft tissue expansion
Vertebral lesions with symptomatic cord compression

Progression and Transformation

2/3 of patients eventually evolve to generalized myeloma or additional solitary or multiple plasmacytomas

Epidemiology and Mortality

Age: 55 years median age
Sex: male predominance
Survival: 1/3 of patients remain disease free at 10 years, median overall survival 10 years


Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Mature B-cell neoplasms
Pages: 250-251

International Classification of Diseases for Oncology, Third Edition, First Revision. Geneva: World Health Organization, 2013.
Section: ICD-O-3.1 (2011) Morphological Codes

National Cancer Institute
Section: General Information About Plasma Cell Neoplasms