This neoplasm is not reportable.

Name

Multicentric Castleman disease

Not Reportable

This neoplasm is not reportable

Alternate Names

Angiofollicular lymph node hyperplasia
Castleman's disease

Definition

A rare disorder in which benign (not cancer) growths form in lymph node tissue. There are two main ways that Castleman disease occurs: localized (unicentric) and multicentric. Unicentric Castleman disease affects only one group of lymph nodes in one part of the body, usually in the chest or abdomen. It may not cause symptoms. Multicentric Castleman disease affects many groups of lymph nodes and lymphoid tissue all through the body. It can weaken the immune system and cause problems such as infection, fever, weight loss, fatigue, night sweats, nerve damage, and anemia. People with Castleman disease have an increased risk of lymphoma.

To report this disease, it must be associated with a lymphoma.

Corresponding ICD-10-CM Codes (U.S. only)

D47.Z2 Castleman disease (effective October 01, 2015)

Sources

Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Mature B-cell neoplasms
Pages: 325-327
Glossary