Search Database ICD-O-3 Code Lists
This neoplasm is not reportable.

Name

In situ mantle cell neoplasia

ICD-O-3 Morphology

9673/1: In situ mantle cell neoplasia
Effective 2021 and later

Reportability

This neoplasm is not reportable

Primary Site(s)

No primary site specified
This neoplasm is reportable for primary sites C700-C729, C751-C753 only.

Abstractor Notes

Low rate of progression. Characterized by the presence of cyclin D1+ cells, most typically in the inner mantle zones of follicles, in lymphoid tissues that do not otherwise suggest the diagnosis of a MCL, and is often found incidentally, sometimes in association with other lymphomas.
ISMCN should be distinguished from overt MCL with a mantle zone growth pattern.

Alternate Names

In situ mantle cell lymphoma
ISMCN
Mantle cell lymphoma-like B cells of uncertain/undetermined significance

Definition

In situ mantle cell neoplasia is defined as the presence of cyclin D1, positive lymphoid cells with CCND1 rearrangements restricted to the mantle zones of otherwise hyperplastic-appearing lymphoid tissue.

Corresponding ICD-9 Codes

238.79 Other lymphatic and hematopoietic tissues

Corresponding ICD-10 Codes

D47.7 Other specified neoplasms of uncertain or unknown behavior of lymphoid, hematopoietic, and related tissue

Corresponding ICD-10-CM Codes (U.S. only)

D47.Z9 Other specified neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue (effective October 01, 2015)

Sources

Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Mature B-cell neoplasms
Pages: 290

International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577

National Cancer Institute
Section: General Information About Adult Non-Hodgkin Lymphoma (NHL)
Pages: https://www.cancer.gov/types/lymphoma/hp/adult-nhl-treatment-pdq
Glossary