This neoplasm is not reportable.

Name

In situ mantle cell neoplasm (ISMCN)

ICD-O-3 Morphology

9673/1: In situ mantle cell neoplasia
Effective 2021 and later

Reportability

This neoplasm is not reportable

Primary Site(s)

No primary site specified
This hematopoietic disease is not reportable for the U.S. except for primary sites C700-C729, C751-C753.
Canada, refer to your specific province for reportability requirements.

Most common primary site: lymph nodes, although can appear in extranodal sites.

Abstractor Notes

In situ mantle cell neoplasm (ISMCN) is part of the Mature B-cell neoplasms lineage table in the WHO 5th edition of Hematolymphoid Tumors. (See Appendix B in the Hematopoietic Manual, Table B15)

ISMCN is most often found in lymph nodes but may be seen in extranodal lymphoid tissues.

Alternate Names

In situ mantle cell lymphoma
In situ mantle cell neoplasia

Definition

In situ mantle cell neoplasm (ISMCN) is defined by the presence of cyclin D1–positive B cells, usually with CCND1 rearrangement, restricted to usually non-expanded mantle zones of lymphoid follicles. (WHO 5th edition)

Corresponding ICD-10 Codes (Cause of Death codes only)

D47.7 Other specified neoplasms of uncertain or unknown behavior of lymphoid, hematopoietic, and related tissue

Corresponding ICD-10-CM Codes (U.S. only)

D47.Z9 Other specified neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue (effective October 01, 2015)

Sources

WHO Classification of Tumours Editorial Board. Haematolymphoid tumours. Lyon (France): International Agency for Research on Cancer; 2024. (WHO classification of tumours series, 5th ed.; vol. 11). https://publications.iarc.who.int/637.
Section: Mantle Cell Lymphoma
Pages: Part B: 444-445

International Classification of Diseases for Oncology, 3rd edition (including revisions). Geneva: World Health Organization, 2001, 2011, 2020.
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577

PDQ® Adult Treatment Editorial Board. PDQ Indolent B-Cell Non-Hodgkin Lymphoma Treatment. Bethesda, MD: National Cancer Institute. Updated <02/18/2025>. Available at: https://www.cancer.gov/types/lymphoma/hp/indolent-b-cell-lymphoma-treatment-pdq. Accessed <03/04/2025>. [PMID: 37437080]
Section: Indolent B-Cell Non-Hodgkin Lymphoma Treatment (PDQ®)–Health Professional Version
Pages: https://www.cancer.gov/types/lymphoma/hp/adult-nhl-treatment-pdq
Glossary