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This neoplasm is not reportable.
Name
HHV8-positive germinotropic lymphoproliferative disorder
ICD-O-3 Morphology
9738/1: HHV8-positive germinotrophic lymphoproliferative disorder
Effective
2021 and later
Reportability
This neoplasm is not reportable
Primary Site(s)
No primary site specified
This neoplasm is reportable for primary sites C700-C729, C751-C753 only.
Abstractor Notes
For cases diagnosed prior to 2010-2020, see code 9738/3.
Per the IARC/WHO Committee for ICD-O and included in the WHO Tumors of Hematopoietic and Lymphoid Tissues, Revised 4th Ed, Volume 2, this histology is now a /1. This change will go into effect for 2021+.
This disorder presents with localized and sometime multifocal lymph node involvement in otherwise healthy individuals.
Per the IARC/WHO Committee for ICD-O and included in the WHO Tumors of Hematopoietic and Lymphoid Tissues, Revised 4th Ed, Volume 2, this histology is now a /1. This change will go into effect for 2021+.
This disorder presents with localized and sometime multifocal lymph node involvement in otherwise healthy individuals.
Alternate Names
GLPD
Definition
HHV8-positive germinotropic lymphoproliferative disorder (GLPD) is a monotypic HHV8-positive lymphoproliferative lesion that usually occurs in HIV-negative individuals. HHV8 plasmablasts partially or completely replace germinal centers. The plasmablasts show either kappa or lambda light chain restriction but are polyclonal or oligoclonal. Coinfection with EBV is characteristic.
Genetics Data
This data item does not apply
Immunophenotyping
This data item does not apply
Corresponding ICD-9 Codes
238.79 Other lymphatic and hematopoietic tissues
Corresponding ICD-10 Codes
D47.7 Other specified neoplasms of uncertain or unknown behavior of lymphoid, hematopoietic, and related tissue
Corresponding ICD-10-CM Codes (U.S. only)
D47.Z9 Other specified neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue (effective October 01, 2015)
Sources
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Mature B-cell neoplasms
Pages: 328-329
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Mature B-cell neoplasms
Pages: 328-329
International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020.
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577
