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This neoplasm is not reportable.
ICD-O-3 Morphology
Effective
2021 and later
Reportability
This neoplasm is not reportable
Primary Site(s)
No primary site specified
This neoplasm is reportable for primary sites C700-C729, C751-C753 only.
Abstractor Notes
Patients with IgM MGUS lack the signs and symptoms of an overt lymphoproliferative disorder of plasma cell neoplasm, and the paraprotein is typically discovered incidentally on serum protein electrophoresis.
Alternate Names
IgM MGUS
Definition
IgM monoclonal gammopathy of undetermined significance (MGUS) is defined by a serum IgM paraprotein concentration < 30 gram per liter; bone marrow lymphoplasmacytic infiltration of < 10%; and no evidence of anemia, constitutional symptoms, hyperviscosity, lymphadenopathy, hepatosplenomegaly, or other end-organ damage that can be attributed to the underlying lymphoproliferative disorder.
IgM MGUS is a precursor condition that may progress to overt lymphoma, lymphoplasmacytic lymphoma (LPL), Waldenstrom macroglobulinemia, or primary amyloidosis.
IgM MGUS is a precursor condition that may progress to overt lymphoma, lymphoplasmacytic lymphoma (LPL), Waldenstrom macroglobulinemia, or primary amyloidosis.
Corresponding ICD-9 Codes
273.1 Monoclonal paraproteinemia
Corresponding ICD-10 Codes
D47.2 Monoclonal gammopathy
Corresponding ICD-10-CM Codes (U.S. only)
D47.2 Monoclonal gammopathy (effective October 01, 2015)
Sources
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds):
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Mature B-cell neoplasms
Pages: 236
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Revised 4th edition)
IARC: Lyon 2017
Section: Mature B-cell neoplasms
Pages: 236
National Cancer Institute
Section: General Information About Plasma Cell Neoplasms
Pages: https://www.cancer.gov/types/myeloma/hp/myeloma-treatment-pdq
Section: General Information About Plasma Cell Neoplasms
Pages: https://www.cancer.gov/types/myeloma/hp/myeloma-treatment-pdq
International Classification of Diseases for Oncology, Third Edition, Second Revision. Geneva: World Health Organization, 2020
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577
Section: ICD-O-3.2 (2020) Morphological Codes
Pages: http://www.iacr.com.fr/index.php?option=com_content&view=category&layout=blog&id=100&Itemid=577
